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Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

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Title: Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.
Authors: Abhishek A; Academic Rheumatology, University of Nottingham, Nottingham, UK. Electronic address: abhishek.abhishek@nottingham.ac.uk., Peckham N; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Pade C; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Gibbons JM; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Cureton L; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Francis A; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Barber V; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Williams JAE; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Appelbe D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Eldridge L; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Julier P; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK., Altmann DM; Department of Inflammation and Immunology, Imperial College London, London, UK., Bluett J; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester UK; Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Brooks T; UK Health Security Agency, UK., Coates LC; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Biomedical Research Centre, Oxford, UK., Rombach I; Sheffield Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, UK., Semper A; UK Health Security Agency, UK., Otter A; UK Health Security Agency, UK., Valdes AM; Academic Rheumatology, University of Nottingham, Nottingham, UK., Nguyen-Van-Tam JS; Population and Lifespan Health, University of Nottingham, Nottingham, UK., Williams HC; Population and Lifespan Health, University of Nottingham, Nottingham, UK., Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., McKnight Á; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Cook JA; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.
Corporate Authors: VROOM study investigators
Source: The Lancet. Rheumatology [Lancet Rheumatol] 2024 Feb; Vol. 6 (2), pp. e92-e104. Date of Electronic Publication: 2023 Dec 12.
Publication Type: Randomized Controlled Trial; Multicenter Study; Journal Article; Equivalence Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101765308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2665-9913 (Electronic) Linking ISSN: 26659913 NLM ISO Abbreviation: Lancet Rheumatol Subsets: MEDLINE
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  Data: Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Abhishek+A%22">Abhishek A</searchLink>; Academic Rheumatology, University of Nottingham, Nottingham, UK. Electronic address: abhishek.abhishek@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Peckham+N%22">Peckham N</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pade+C%22">Pade C</searchLink>; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gibbons+JM%22">Gibbons JM</searchLink>; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cureton+L%22">Cureton L</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Francis+A%22">Francis A</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Barber+V%22">Barber V</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Williams+JAE%22">Williams JAE</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Appelbe+D%22">Appelbe D</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Eldridge+L%22">Eldridge L</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Julier+P%22">Julier P</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Altmann+DM%22">Altmann DM</searchLink>; Department of Inflammation and Immunology, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bluett+J%22">Bluett J</searchLink>; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester UK; Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Brooks+T%22">Brooks T</searchLink>; UK Health Security Agency, UK.<br /><searchLink fieldCode="AU" term="%22Coates+LC%22">Coates LC</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rombach+I%22">Rombach I</searchLink>; Sheffield Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Semper+A%22">Semper A</searchLink>; UK Health Security Agency, UK.<br /><searchLink fieldCode="AU" term="%22Otter+A%22">Otter A</searchLink>; UK Health Security Agency, UK.<br /><searchLink fieldCode="AU" term="%22Valdes+AM%22">Valdes AM</searchLink>; Academic Rheumatology, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Nguyen-Van-Tam+JS%22">Nguyen-Van-Tam JS</searchLink>; Population and Lifespan Health, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Williams+HC%22">Williams HC</searchLink>; Population and Lifespan Health, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Boyton+RJ%22">Boyton RJ</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22McKnight+Á%22">McKnight Á</searchLink>; Blizard Institute, Centre for Genomics and Child Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cook+JA%22">Cook JA</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.
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  Data: <searchLink fieldCode="JN" term="%22101765308%22">The Lancet. Rheumatology</searchLink> [Lancet Rheumatol] 2024 Feb; Vol. 6 (2), pp. e92-e104. <i>Date of Electronic Publication: </i>2023 Dec 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101765308 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2665-9913 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226659913%22">26659913 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Rheumatol <i>Subsets: </i>MEDLINE
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