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Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.

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Title: Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
Authors: Seddighi S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Qi YA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Brown AL; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Wilkins OG; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; Francis Crick Institute, London, UK., Bereda C; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Belair C; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Keuss MJ; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Khandeshi A; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Pickles S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Kargbo-Hill SE; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Hawrot J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Ramos DM; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Yuan H; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Roberts J; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sacramento EK; Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745 Jena, Germany., Shah SI; Data Tecnica International, Washington, DC, USA., Nalls MA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Colón-Mercado JM; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Reyes JF; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Ryan VH; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nelson MP; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Cook CN; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Li Z; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Screven L; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kwan JY; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Mehta PR; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Zanovello M; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Hallegger M; Francis Crick Institute, London, UK.; UK Dementia Research Institute at King's College London, London, UK., Shantaraman A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Ping L; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Koike Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Oskarsson B; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Staff NP; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Duong DM; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Ahmed A; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Secrier M; Department of Genetics, Evolution and Environment, UCL Genetics Institute, UCL, London, UK., Ule J; Francis Crick Institute, London, UK.; UK Dementia Research Institute at King's College London, London, UK., Jacobson S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Reich DS; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Rohrer JD; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Malaspina A; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Glass JD; Department of Neurology, Center for Neurodegenerative Diseases, Emory University, Atlanta, GA, USA., Ori A; Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745 Jena, Germany., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Maragkakis M; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Fratta P; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; Francis Crick Institute, London, UK., Ward ME; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Feb 14; Vol. 16 (734), pp. eadg7162. Date of Electronic Publication: 2024 Feb 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
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  Data: <searchLink fieldCode="AU" term="%22Seddighi+S%22">Seddighi S</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Qi+YA%22">Qi YA</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brown+AL%22">Brown AL</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Wilkins+OG%22">Wilkins OG</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Bereda+C%22">Bereda C</searchLink>; 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Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Screven+L%22">Screven L</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kwan+JY%22">Kwan JY</searchLink>; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+PR%22">Mehta PR</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Zanovello+M%22">Zanovello M</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Hallegger+M%22">Hallegger M</searchLink>; 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      – PersonEntity:
          Name:
            NameFull: Maragkakis M
      – PersonEntity:
          Name:
            NameFull: Petrucelli L
      – PersonEntity:
          Name:
            NameFull: Fratta P
      – PersonEntity:
          Name:
            NameFull: Ward ME
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 14
              M: 02
              Text: 2024 Feb 14
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 734
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1