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MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans.

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Title: MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans.
Authors: Mayer L; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. l.mayer@uke.de.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. l.mayer@uke.de.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany. l.mayer@uke.de., Weskamm LM; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Fathi A; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; First Department of Medicine, Division of Infectious Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Kono M; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Heidepriem J; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Krähling V; Institute for Virology, Philipps University Marburg, Marburg, Germany.; German Centre for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany., Mellinghoff SC; Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), German CLL Group (GCLLSG), University of Cologne, Cologne, Germany.; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany., Ly ML; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Friedrich M; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Hardtke S; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Borregaard S; Clinical Trial Center North GmbH & Co. KG, Hamburg, Germany., Hesterkamp T; German Centre for Infection Research, Translational Project Management Office, Brunswick, Germany., Loeffler FF; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Volz A; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.; German Centre for Infection Research, Partner Site Hannover-Brunswick, Hanover, Germany., Sutter G; Division of Virology, Department of Veterinary Sciences, Institute for Infectious Diseases and Zoonoses, LMU Munich, Munich, Germany.; German Centre for Infection Research, Partner Site Munich, Munich, Germany., Becker S; Institute for Virology, Philipps University Marburg, Marburg, Germany.; German Centre for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany., Dahlke C; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Addo MM; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. m.addo@uke.de.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. m.addo@uke.de.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany. m.addo@uke.de.
Source: NPJ vaccines [NPJ Vaccines] 2024 Jan 26; Vol. 9 (1), pp. 20. Date of Electronic Publication: 2024 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans.
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  Data: <searchLink fieldCode="AU" term="%22Mayer+L%22">Mayer L</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. l.mayer@uke.de.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. l.mayer@uke.de.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany. l.mayer@uke.de.<br /><searchLink fieldCode="AU" term="%22Weskamm+LM%22">Weskamm LM</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fathi+A%22">Fathi A</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; First Department of Medicine, Division of Infectious Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kono+M%22">Kono M</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heidepriem+J%22">Heidepriem J</searchLink>; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Krähling+V%22">Krähling V</searchLink>; Institute for Virology, Philipps University Marburg, Marburg, Germany.; German Centre for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mellinghoff+SC%22">Mellinghoff SC</searchLink>; Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), German CLL Group (GCLLSG), University of Cologne, Cologne, Germany.; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ly+ML%22">Ly ML</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Friedrich+M%22">Friedrich M</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hardtke+S%22">Hardtke S</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Borregaard+S%22">Borregaard S</searchLink>; Clinical Trial Center North GmbH & Co. KG, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hesterkamp+T%22">Hesterkamp T</searchLink>; German Centre for Infection Research, Translational Project Management Office, Brunswick, Germany.<br /><searchLink fieldCode="AU" term="%22Loeffler+FF%22">Loeffler FF</searchLink>; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Volz+A%22">Volz A</searchLink>; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.; German Centre for Infection Research, Partner Site Hannover-Brunswick, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Sutter+G%22">Sutter G</searchLink>; Division of Virology, Department of Veterinary Sciences, Institute for Infectious Diseases and Zoonoses, LMU Munich, Munich, Germany.; German Centre for Infection Research, Partner Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+S%22">Becker S</searchLink>; Institute for Virology, Philipps University Marburg, Marburg, Germany.; German Centre for Infection Research, Partner Site Gießen-Marburg-Langen, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dahlke+C%22">Dahlke C</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Addo+MM%22">Addo MM</searchLink>; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. m.addo@uke.de.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. m.addo@uke.de.; German Centre for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany. m.addo@uke.de.
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  Data: <searchLink fieldCode="JN" term="%22101699863%22">NPJ vaccines</searchLink> [NPJ Vaccines] 2024 Jan 26; Vol. 9 (1), pp. 20. <i>Date of Electronic Publication: </i>2024 Jan 26.
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