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A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.

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Title: A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.
Authors: Desroys du Roure P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Lajoie L; Université de Tours - INRAE, UMR1282, Infectiologie et Santé Publique (ISP), équipe BioMédicaments Anti-Parasitaires (BioMAP), Tours, France., Mallavialle A; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Alcaraz LB; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Mansouri H; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; RHEM, IRCM, Montpellier, France., Fenou L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Garambois V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Rubio L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., David T; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Coenon L; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France., Boissière-Michot F; Translational Research Unit, ICM, Montpellier, France., Chateau MC; Translational Research Unit, ICM, Montpellier, France., Ngo G; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Jarlier M; Biometry Department, ICM, Montpellier, France., Villalba M; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France.; Institut du Cancer Avignon-Provence Sainte Catherine, Avignon, France., Martineau P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Laurent-Matha V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Roger P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Pathology, CHU Nîmes, Nimes, France., Guiu S; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Medical Oncology, ICM, Montpellier, France., Chardès T; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France., Gros L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France., Liaudet-Coopman E; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France emmanuelle.liaudet-coopman@inserm.fr.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jan 30; Vol. 12 (1). Date of Electronic Publication: 2024 Jan 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Desroys+du+Roure+P%22">Desroys du Roure P</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Lajoie+L%22">Lajoie L</searchLink>; Université de Tours - INRAE, UMR1282, Infectiologie et Santé Publique (ISP), équipe BioMédicaments Anti-Parasitaires (BioMAP), Tours, France.<br /><searchLink fieldCode="AU" term="%22Mallavialle+A%22">Mallavialle A</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Alcaraz+LB%22">Alcaraz LB</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Mansouri+H%22">Mansouri H</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; RHEM, IRCM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Fenou+L%22">Fenou L</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Garambois+V%22">Garambois V</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Rubio+L%22">Rubio L</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22David+T%22">David T</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Coenon+L%22">Coenon L</searchLink>; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Boissière-Michot+F%22">Boissière-Michot F</searchLink>; Translational Research Unit, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Chateau+MC%22">Chateau MC</searchLink>; Translational Research Unit, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Ngo+G%22">Ngo G</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Jarlier+M%22">Jarlier M</searchLink>; Biometry Department, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Villalba+M%22">Villalba M</searchLink>; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France.; Institut du Cancer Avignon-Provence Sainte Catherine, Avignon, France.<br /><searchLink fieldCode="AU" term="%22Martineau+P%22">Martineau P</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Laurent-Matha+V%22">Laurent-Matha V</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Roger+P%22">Roger P</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Pathology, CHU Nîmes, Nimes, France.<br /><searchLink fieldCode="AU" term="%22Guiu+S%22">Guiu S</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Medical Oncology, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Chardès+T%22">Chardès T</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France.<br /><searchLink fieldCode="AU" term="%22Gros+L%22">Gros L</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France.<br /><searchLink fieldCode="AU" term="%22Liaudet-Coopman+E%22">Liaudet-Coopman E</searchLink>; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France emmanuelle.liaudet-coopman@inserm.fr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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