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Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol.

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Title: Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol.
Authors: Zhang Y; Division of General Medicine, Columbia University, New York, New York., Dron JS; Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.; Center for Genomic Medicine, Massachusetts General Hospital, Boston., Bellows BK; Division of General Medicine, Columbia University, New York, New York., Khera AV; Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts., Liu J; Department of Population Health Science and Policy, Icahn School of Medicine, Mount Sinai, New York, New York., Balte PP; Division of General Medicine, Columbia University, New York, New York., Oelsner EC; Division of General Medicine, Columbia University, New York, New York., Amr SS; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts., Lebo MS; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts., Nagy A; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Natarajan P; Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Boston., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California., Willer C; Department of Internal Medicine, University of Michigan, Ann Arbor.; Department of Human Genetics, University of Michigan, Ann Arbor.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, Texas., Lutsey PL; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis., Fornage M; The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston., Lloyd-Jones DM; Northwestern University, Chicago, Illinois., Hou L; Northwestern University, Chicago, Illinois., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle.; Department of Health Systems and Population Health, University of Washington, Seattle., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle., Vasan RS; The Framingham Heart Study, Framingham, Massachusetts.; Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Heard-Costa NL; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California., Kazi DS; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts., de Ferranti SD; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts., Moran AE; Division of General Medicine, Columbia University, New York, New York.
Source: JAMA cardiology [JAMA Cardiol] 2024 Mar 01; Vol. 9 (3), pp. 263-271.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101676033 Publication Model: Print Cited Medium: Internet ISSN: 2380-6591 (Electronic) NLM ISO Abbreviation: JAMA Cardiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of General Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Dron+JS%22">Dron JS</searchLink>; Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.; Center for Genomic Medicine, Massachusetts General Hospital, Boston.<br /><searchLink fieldCode="AU" term="%22Bellows+BK%22">Bellows BK</searchLink>; Division of General Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Khera+AV%22">Khera AV</searchLink>; Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Population Health Science and Policy, Icahn School of Medicine, Mount Sinai, New York, New York.<br /><searchLink fieldCode="AU" term="%22Balte+PP%22">Balte PP</searchLink>; Division of General Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Oelsner+EC%22">Oelsner EC</searchLink>; Division of General Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Amr+SS%22">Amr SS</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lebo+MS%22">Lebo MS</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Nagy+A%22">Nagy A</searchLink>; Laboratory for Molecular Medicine, Personalized Medicine, Mass General Brigham, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; 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Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston.<br /><searchLink fieldCode="AU" term="%22Ballantyne+CM%22">Ballantyne CM</searchLink>; Department of Medicine, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Lutsey+PL%22">Lutsey PL</searchLink>; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston.<br /><searchLink fieldCode="AU" term="%22Lloyd-Jones+DM%22">Lloyd-Jones DM</searchLink>; Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle.; Department of Health Systems and Population Health, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Floyd+JS%22">Floyd JS</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Vasan+RS%22">Vasan RS</searchLink>; The Framingham Heart Study, Framingham, Massachusetts.; Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Heard-Costa+NL%22">Heard-Costa NL</searchLink>; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Carson+AP%22">Carson AP</searchLink>; Department of Medicine, University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Hall+ME%22">Hall ME</searchLink>; Department of Medicine, University of Mississippi Medical Center, Jackson.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California.<br /><searchLink fieldCode="AU" term="%22Kazi+DS%22">Kazi DS</searchLink>; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Richard A. and Susan F. 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