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Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.

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Title: Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
Authors: MacLeod AK; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Coquelin KS; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom., Huertas L; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Simeons FRC; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Casado P; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Guijarro L; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Casanueva R; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Frame L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Pinto EG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Ferguson L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Duncan C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Mutter N; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Shishikura Y; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom., Henderson CJ; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom., Cebrian D; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Wolf CR; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 13; Vol. 121 (7), pp. e2315069121. Date of Electronic Publication: 2024 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22MacLeod+AK%22">MacLeod AK</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Coquelin+KS%22">Coquelin KS</searchLink>; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huertas+L%22">Huertas L</searchLink>; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Simeons+FRC%22">Simeons FRC</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Casado+P%22">Casado P</searchLink>; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Guijarro+L%22">Guijarro L</searchLink>; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Casanueva+R%22">Casanueva R</searchLink>; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Frame+L%22">Frame L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pinto+EG%22">Pinto EG</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ferguson+L%22">Ferguson L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Duncan+C%22">Duncan C</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mutter+N%22">Mutter N</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shishikura+Y%22">Shishikura Y</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Henderson+CJ%22">Henderson CJ</searchLink>; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cebrian+D%22">Cebrian D</searchLink>; Global Health Research & Development, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Wolf+CR%22">Wolf CR</searchLink>; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, United Kingdom.
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