SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming.

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Title: SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming.
Authors: Xu X; RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Yu Y; Department of Hematology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China., Zhang W; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Ma W; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., He C; RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Qiu G; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Wang X; RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Liu Q; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Zhao M; Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China., Xie J; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Tao F; Children's Mercy Hospital, University of Kansas Medical Center, University of Missouri, Kansas City, MO, USA., Perry JM; Children's Mercy Hospital, University of Kansas Medical Center, University of Missouri, Kansas City, MO, USA., Liu Q; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Rao S; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. raoshuan1@smu.edu.cn., Kang X; Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, MO, USA. kangxu@health.missouri.edu., Zhao M; RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhaom38@mail.sysu.edu.cn.; Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong, China. zhaom38@mail.sysu.edu.cn.; Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhaom38@mail.sysu.edu.cn., Jiang L; RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. jianglj7@mail.sysu.edu.cn.
Source: Nature cell biology [Nat Cell Biol] 2024 Mar; Vol. 26 (3), pp. 464-477. Date of Electronic Publication: 2024 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/s41556-024-01349-3