Convergence of coronary artery disease genes onto endothelial cell programs.

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Title: Convergence of coronary artery disease genes onto endothelial cell programs.
Authors: Schnitzler GR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Fang S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Angom RS; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA., Lee-Kim VS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Ma XR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Zhou R; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Zeng T; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Guo K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Taylor MS; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Vellarikkal SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Barry AE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sias-Garcia O; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bloemendal A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Guckelberger P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Hinshaw S; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Cheng N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cleary B; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Computing and Data Sciences, Departments of Biology and Biomedical Engineering, Biological Design Center, and Program in Bioinformatics, Boston University, Boston, MA, USA., Aragam K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mukhopadhyay D; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA., Gupta RM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rgupta@bwh.harvard.edu.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA. rgupta@bwh.harvard.edu.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. rgupta@bwh.harvard.edu., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA. engreitz@stanford.edu.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. engreitz@stanford.edu.
Source: Nature [Nature] 2024 Feb; Vol. 626 (8000), pp. 799-807. Date of Electronic Publication: 2024 Feb 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Convergence of coronary artery disease genes onto endothelial cell programs.
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  Data: <searchLink fieldCode="AU" term="%22Schnitzler+GR%22">Schnitzler GR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+H%22">Kang H</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fang+S%22">Fang S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Angom+RS%22">Angom RS</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lee-Kim+VS%22">Lee-Kim VS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+XR%22">Ma XR</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+T%22">Zeng T</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+K%22">Guo K</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+MS%22">Taylor MS</searchLink>; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vellarikkal+SK%22">Vellarikkal SK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barry+AE%22">Barry AE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sias-Garcia+O%22">Sias-Garcia O</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bloemendal+A%22">Bloemendal A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Munson+G%22">Munson G</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guckelberger+P%22">Guckelberger P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TH%22">Nguyen TH</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bergman+DT%22">Bergman DT</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Hinshaw+S%22">Hinshaw S</searchLink>; Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+N%22">Cheng N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cleary+B%22">Cleary B</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Computing and Data Sciences, Departments of Biology and Biomedical Engineering, Biological Design Center, and Program in Bioinformatics, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aragam+K%22">Aragam K</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lander+ES%22">Lander ES</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Finucane+HK%22">Finucane HK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+D%22">Mukhopadhyay D</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+RM%22">Gupta RM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rgupta@bwh.harvard.edu.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA. rgupta@bwh.harvard.edu.; Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. rgupta@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Engreitz+JM%22">Engreitz JM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA. engreitz@stanford.edu.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. engreitz@stanford.edu.
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