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The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity.

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Title: The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity.
Authors: Santavanond JP; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Chiu YH; Departments of Medical Science, Life Science, and Medicine, National Tsing Hua University, Hsinchu, Taiwan. yhchiu@life.nthu.edu.tw.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. yhchiu@life.nthu.edu.tw., Tixeira R; Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Liu Z; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Yap JKY; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Chen KW; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Li CL; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Lu YR; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Roncero-Carol J; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Hoijman E; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Rutter SF; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Shi B; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Ryan GF; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Hodge AL; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Caruso S; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Baxter AA; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Ozkocak DC; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Johnson C; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia., Day ZI; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia., Mayfosh AJ; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia., Hulett MD; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia., Phan TK; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.; The Walter and Eliza Hall Institute of Medial Research, Parkville, Vic, Australia., Atkin-Smith GK; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.; The Walter and Eliza Hall Institute of Medial Research, Parkville, Vic, Australia.; University of Melbourne, Melbourne, VIC, Australia., Poon IKH; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia. i.poon@latrobe.edu.au.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia. i.poon@latrobe.edu.au.
Source: Cell death & disease [Cell Death Dis] 2024 Feb 09; Vol. 15 (2), pp. 123. Date of Electronic Publication: 2024 Feb 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity.
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  Data: <searchLink fieldCode="AU" term="%22Santavanond+JP%22">Santavanond JP</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chiu+YH%22">Chiu YH</searchLink>; Departments of Medical Science, Life Science, and Medicine, National Tsing Hua University, Hsinchu, Taiwan. yhchiu@life.nthu.edu.tw.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. yhchiu@life.nthu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Tixeira+R%22">Tixeira R</searchLink>; Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yap+JKY%22">Yap JKY</searchLink>; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+KW%22">Chen KW</searchLink>; Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+CL%22">Li CL</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+YR%22">Lu YR</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Roncero-Carol+J%22">Roncero-Carol J</searchLink>; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hoijman+E%22">Hoijman E</searchLink>; Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.; Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rutter+SF%22">Rutter SF</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Shi+B%22">Shi B</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ryan+GF%22">Ryan GF</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hodge+AL%22">Hodge AL</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Caruso+S%22">Caruso S</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Baxter+AA%22">Baxter AA</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ozkocak+DC%22">Ozkocak DC</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Johnson+C%22">Johnson C</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Day+ZI%22">Day ZI</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Mayfosh+AJ%22">Mayfosh AJ</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Hulett+MD%22">Hulett MD</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Phan+TK%22">Phan TK</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.; The Walter and Eliza Hall Institute of Medial Research, Parkville, Vic, Australia.<br /><searchLink fieldCode="AU" term="%22Atkin-Smith+GK%22">Atkin-Smith GK</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia.; The Walter and Eliza Hall Institute of Medial Research, Parkville, Vic, Australia.; University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Poon+IKH%22">Poon IKH</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia. i.poon@latrobe.edu.au.; Research Centre of Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia. i.poon@latrobe.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2024 Feb 09; Vol. 15 (2), pp. 123. <i>Date of Electronic Publication: </i>2024 Feb 09.
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