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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.

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Title: p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.
Authors: Fondevila MF; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain. Electronic address: marcos.fernandez.fondevila@gmail.com., Novoa E; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Gonzalez-Rellan MJ; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Fernandez U; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain., Heras V; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Porteiro B; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Parracho T; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Dorta V; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Riobello C; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., da Silva Lima N; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Seoane S; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Garcia-Vence M; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain., Chantada-Vazquez MP; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain., Bravo SB; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain., Senra A; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Leiva M; Department of Immunology, Ophthalmology, & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., Marcos M; University of Salamanca, Department of Internal Medicine, University Hospital of Salamanca-IBSAL, 37008 Salamanca, Spain., Sabio G; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain., Perez-Fernandez R; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Dieguez C; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Prevot V; University Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, European Genomic Institute for Diabetes (EGID), 59000 Lille, France., Schwaninger M; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, 23562 Lübeck, Germany., Woodhoo A; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Martinez-Chantar ML; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain., Schwabe R; Department of Medicine, Columbia University, New York, NY 10027, USA., Cubero FJ; Department of Immunology, Ophthalmology, & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., Varela-Rey M; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain., Crespo J; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain., Iruzubieta P; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain., Nogueiras R; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Galicia Agency of Innovation (GAIN), Xunta de Galicia, 15702 Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
Source: Cell reports. Medicine [Cell Rep Med] 2024 Feb 20; Vol. 5 (2), pp. 101401. Date of Electronic Publication: 2024 Feb 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Fondevila+MF%22">Fondevila MF</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain. Electronic address: marcos.fernandez.fondevila@gmail.com.<br /><searchLink fieldCode="AU" term="%22Novoa+E%22">Novoa E</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+U%22">Fernandez U</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Heras+V%22">Heras V</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Porteiro+B%22">Porteiro B</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Parracho+T%22">Parracho T</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Dorta+V%22">Dorta V</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Riobello+C%22">Riobello C</searchLink>; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22da+Silva+Lima+N%22">da Silva Lima N</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Seoane+S%22">Seoane S</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Vence+M%22">Garcia-Vence M</searchLink>; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Chantada-Vazquez+MP%22">Chantada-Vazquez MP</searchLink>; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Bravo+SB%22">Bravo SB</searchLink>; Proteomic Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15705 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Senra+A%22">Senra A</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Leiva+M%22">Leiva M</searchLink>; Department of Immunology, Ophthalmology, & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marcos+M%22">Marcos M</searchLink>; University of Salamanca, Department of Internal Medicine, University Hospital of Salamanca-IBSAL, 37008 Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Sabio+G%22">Sabio G</searchLink>; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Fernandez+R%22">Perez-Fernandez R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Dieguez+C%22">Dieguez C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Prevot+V%22">Prevot V</searchLink>; University Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, European Genomic Institute for Diabetes (EGID), 59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Schwaninger+M%22">Schwaninger M</searchLink>; University of Lübeck, Institute for Experimental and Clinical Pharmacology and Toxicology, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Woodhoo+A%22">Woodhoo A</searchLink>; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Chantar+ML%22">Martinez-Chantar ML</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Schwabe+R%22">Schwabe R</searchLink>; Department of Medicine, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Cubero+FJ%22">Cubero FJ</searchLink>; Department of Immunology, Ophthalmology, & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain; CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Varela-Rey+M%22">Varela-Rey M</searchLink>; Gene Regulatory Control in Disease Laboratory, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+J%22">Crespo J</searchLink>; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Iruzubieta+P%22">Iruzubieta P</searchLink>; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, 39008 Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), 15782 Santiago de Compostela, Spain; Galicia Agency of Innovation (GAIN), Xunta de Galicia, 15702 Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
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