Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
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| Title: | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. |
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| Authors: | Gimenez LE; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Martin C; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Yu J; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Hollanders C; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States., Wu Y; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Yao D; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Han GW; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California 90089, United States., Dahir NS; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States., Wu L; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Van der Poorten O; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Lamouroux A; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Mannes M; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Zhao S; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Tourwé D; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium., Stevens RC; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China., Cone RD; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan 48109, United States., Ballet S; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2690-2711. Date of Electronic Publication: 2024 Feb 12. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38345933 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gimenez+LE%22">Gimenez LE</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.<br /><searchLink fieldCode="AU" term="%22Martin+C%22">Martin C</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Hollanders+C%22">Hollanders C</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Hernandez+CC%22">Hernandez CC</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Yao+D%22">Yao D</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Han+GW%22">Han GW</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California 90089, United States.<br /><searchLink fieldCode="AU" term="%22Dahir+NS%22">Dahir NS</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Van+der+Poorten+O%22">Van der Poorten O</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Lamouroux+A%22">Lamouroux A</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Mannes+M%22">Mannes M</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Tourwé+D%22">Tourwé D</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Cone+RD%22">Cone RD</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, Michigan 48109, United States.<br /><searchLink fieldCode="AU" term="%22Ballet+S%22">Ballet S</searchLink>; Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2690-2711. <i>Date of Electronic Publication: </i>2024 Feb 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38345933 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.3c01822 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2690 Titles: – TitleFull: Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gimenez LE – PersonEntity: Name: NameFull: Martin C – PersonEntity: Name: NameFull: Yu J – PersonEntity: Name: NameFull: Hollanders C – PersonEntity: Name: NameFull: Hernandez CC – PersonEntity: Name: NameFull: Wu Y – PersonEntity: Name: NameFull: Yao D – PersonEntity: Name: NameFull: Han GW – PersonEntity: Name: NameFull: Dahir NS – PersonEntity: Name: NameFull: Wu L – PersonEntity: Name: NameFull: Van der Poorten O – PersonEntity: Name: NameFull: Lamouroux A – PersonEntity: Name: NameFull: Mannes M – PersonEntity: Name: NameFull: Zhao S – PersonEntity: Name: NameFull: Tourwé D – PersonEntity: Name: NameFull: Stevens RC – PersonEntity: Name: NameFull: Cone RD – PersonEntity: Name: NameFull: Ballet S IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 02 Text: 2024 Feb 22 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 67 – Type: issue Value: 4 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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