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ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.

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Title: ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
Authors: Bassani B; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Simonetti G; Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Cancila V; Tumor Immunology Unit, Department of Health Sciences, Human Pathology Section, School of Medicine, University of Palermo, 90133 Palermo, Italy., Fiorino A; Predictive Medicine: Molecular Bases of Genetic Risk Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Ciciarello M; CNR Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza,' Unit of Bologna, Bologna, Italy; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Piva A; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Khorasani AM; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Chiodoni C; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Lecis D; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Gulino A; CGT Lab, Cogentech Società Benefit, Catania, Italy., Fonzi E; Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori,' Meldola, Forlì-Cesena, Italy., Botti L; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Portararo P; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Costanza M; Neuro-Oncology Unit, Department of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Brambilla M; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Colombo G; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy., Schwaller J; University Children's Hospital Basel & Department of Biomedicine, University of Basel, Basel, Switzerland., Tzankov A; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Ponzoni M; IRCCS Ospedale S. Raffaele, University Vita-Salute San Raffaele, Milan, Italy., Ciceri F; IRCCS Ospedale S. Raffaele, University Vita-Salute San Raffaele, Milan, Italy., Bolli N; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy., Curti A; Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology 'Seràgnoli,' Bologna, Italy., Tripodo C; Tumor Immunology Unit, Department of Health Sciences, Human Pathology Section, School of Medicine, University of Palermo, 90133 Palermo, Italy; IFOM-ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Colombo MP; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: mariopaolo.colombo@istitutotumori.mi.it., Sangaletti S; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: sabina.sangaletti@istitutotumori.mi.it.
Source: Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113794. Date of Electronic Publication: 2024 Feb 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
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  Data: <searchLink fieldCode="AU" term="%22Bassani+B%22">Bassani B</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Simonetti+G%22">Simonetti G</searchLink>; Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Cancila+V%22">Cancila V</searchLink>; Tumor Immunology Unit, Department of Health Sciences, Human Pathology Section, School of Medicine, University of Palermo, 90133 Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Fiorino+A%22">Fiorino A</searchLink>; Predictive Medicine: Molecular Bases of Genetic Risk Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ciciarello+M%22">Ciciarello M</searchLink>; CNR Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza,' Unit of Bologna, Bologna, Italy; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Piva+A%22">Piva A</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Khorasani+AM%22">Khorasani AM</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Chiodoni+C%22">Chiodoni C</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lecis+D%22">Lecis D</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gulino+A%22">Gulino A</searchLink>; CGT Lab, Cogentech Società Benefit, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Fonzi+E%22">Fonzi E</searchLink>; Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori,' Meldola, Forlì-Cesena, Italy.<br /><searchLink fieldCode="AU" term="%22Botti+L%22">Botti L</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Portararo+P%22">Portararo P</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Costanza+M%22">Costanza M</searchLink>; Neuro-Oncology Unit, Department of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brambilla+M%22">Brambilla M</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+G%22">Colombo G</searchLink>; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Schwaller+J%22">Schwaller J</searchLink>; University Children's Hospital Basel & Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tzankov+A%22">Tzankov A</searchLink>; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ponzoni+M%22">Ponzoni M</searchLink>; IRCCS Ospedale S. Raffaele, University Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ciceri+F%22">Ciceri F</searchLink>; IRCCS Ospedale S. Raffaele, University Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bolli+N%22">Bolli N</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Curti+A%22">Curti A</searchLink>; Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology 'Seràgnoli,' Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Tripodo+C%22">Tripodo C</searchLink>; Tumor Immunology Unit, Department of Health Sciences, Human Pathology Section, School of Medicine, University of Palermo, 90133 Palermo, Italy; IFOM-ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+MP%22">Colombo MP</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: mariopaolo.colombo@istitutotumori.mi.it.<br /><searchLink fieldCode="AU" term="%22Sangaletti+S%22">Sangaletti S</searchLink>; Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: sabina.sangaletti@istitutotumori.mi.it.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113794. <i>Date of Electronic Publication: </i>2024 Feb 15.
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