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The Italian Multicentric Randomized OPTkIMA Trial on Fixed vs Progressive Intermittent TKI Therapy in CML Elderly Patients: 3-Years of Molecular Response and Quality of Life Monitoring After Completing the Treatment Plan.

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Title: The Italian Multicentric Randomized OPTkIMA Trial on Fixed vs Progressive Intermittent TKI Therapy in CML Elderly Patients: 3-Years of Molecular Response and Quality of Life Monitoring After Completing the Treatment Plan.
Authors: Malagola M; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy. Electronic address: michelemalagola@yahoo.it., Iurlo A; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Bucelli C; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Abruzzese E; Division of Hematology, S. Eugenio Hospital, ASL ROMA2, Tor Vergata University, Roma, Italy., Bonifacio M; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area - University of Verona, Italy., Stagno F; Hematology Unit, AOU Policlinico 'G. Martino', University of Messina, Italy., Binotto G; Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, Italy., D'Adda M; Division of Hematology, ASST-Spedali Civili di Brescia, Brescia, Italy., Lunghi M; Division of Hematology, Department of Translation Medicine, University of Eastern Piedmont, Novara, Italy., Crugnola M; Hematology Unit and BMT Center University Hospital of Parma, Italy., Ferrari ML; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Lunghi F; Hematology and Bone Marrow Transplantation (BMT) Unit, San Raffaele Scientific Institute, Milano, Italy., Castagnetti F; Institute of Hematology 'Seràgnoli' IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; Department of Medical and Surgical Sciences University of Bologna, Bologna, Italy., Rosti G; IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola (FC), Italy., Lemoli RM; Chair of Hematology, Internal Medicine Dpt, University of Genova, Italy; Clinic of Hematology, IRCCS Policlinico San Martino, Genova, Italy., Sancetta R; Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy., Coppi MR; Haematology and BMT Unit 'Antonio Perrino' Hospital, Brindisi, Italy., Corsetti MT; Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., De Gobbi M; Hematology and Internal Medicine Division, San Luigi Hospital, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy., Romano A; IRCCS Regina Elena National Cancer Institute-Roma, Italy., Tiribelli M; Division of Hematology and BMT, Department of Medicine, University of Udine, Udine, Italy., Russo Rossi A; Hematology and Transplants Unit, University of Bari, Bari, Italy., Russo S; Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva, Policlinico G Martino, University of Messina, Messina, Italy., Defina M; Hematology Unit, Dipartimento Terapie Cellulari, Ematologia e Medicina di Laboratorio, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy., Farina M; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy., Bernardi S; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy; CREA Laboratory (Hematological-Research AIL Centre), ASST-Spedali Civili Brescia, Italy., Butturini G; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy., Pellizzeri S; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy., Roccaro AM; Clinical Trial Center. Translational Research and Phase I Unit, ASST Spedali Civili, Brescia, Italy., Russo D; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy.
Source: Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2024 May; Vol. 24 (5), pp. 323-331. Date of Electronic Publication: 2024 Jan 25.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101525386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-2669 (Electronic) Linking ISSN: 21522669 NLM ISO Abbreviation: Clin Lymphoma Myeloma Leuk Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Italian Multicentric Randomized OPTkIMA Trial on Fixed vs Progressive Intermittent TKI Therapy in CML Elderly Patients: 3-Years of Molecular Response and Quality of Life Monitoring After Completing the Treatment Plan.
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  Data: <searchLink fieldCode="AU" term="%22Malagola+M%22">Malagola M</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy. Electronic address: michelemalagola@yahoo.it.<br /><searchLink fieldCode="AU" term="%22Iurlo+A%22">Iurlo A</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Bucelli+C%22">Bucelli C</searchLink>; Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Abruzzese+E%22">Abruzzese E</searchLink>; Division of Hematology, S. Eugenio Hospital, ASL ROMA2, Tor Vergata University, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Bonifacio+M%22">Bonifacio M</searchLink>; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area - University of Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Stagno+F%22">Stagno F</searchLink>; Hematology Unit, AOU Policlinico 'G. Martino', University of Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Binotto+G%22">Binotto G</searchLink>; Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22D'Adda+M%22">D'Adda M</searchLink>; Division of Hematology, ASST-Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Lunghi+M%22">Lunghi M</searchLink>; Division of Hematology, Department of Translation Medicine, University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Crugnola+M%22">Crugnola M</searchLink>; Hematology Unit and BMT Center University Hospital of Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+ML%22">Ferrari ML</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Lunghi+F%22">Lunghi F</searchLink>; Hematology and Bone Marrow Transplantation (BMT) Unit, San Raffaele Scientific Institute, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Castagnetti+F%22">Castagnetti F</searchLink>; Institute of Hematology 'Seràgnoli' IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; Department of Medical and Surgical Sciences University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rosti+G%22">Rosti G</searchLink>; IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola (FC), Italy.<br /><searchLink fieldCode="AU" term="%22Lemoli+RM%22">Lemoli RM</searchLink>; Chair of Hematology, Internal Medicine Dpt, University of Genova, Italy; Clinic of Hematology, IRCCS Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Sancetta+R%22">Sancetta R</searchLink>; Hematology Unit, Dell'Angelo Hospital, Venezia-Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Coppi+MR%22">Coppi MR</searchLink>; Haematology and BMT Unit 'Antonio Perrino' Hospital, Brindisi, Italy.<br /><searchLink fieldCode="AU" term="%22Corsetti+MT%22">Corsetti MT</searchLink>; Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22De+Gobbi+M%22">De Gobbi M</searchLink>; Hematology and Internal Medicine Division, San Luigi Hospital, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Romano+A%22">Romano A</searchLink>; IRCCS Regina Elena National Cancer Institute-Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Tiribelli+M%22">Tiribelli M</searchLink>; Division of Hematology and BMT, Department of Medicine, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+Rossi+A%22">Russo Rossi A</searchLink>; Hematology and Transplants Unit, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+S%22">Russo S</searchLink>; Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva, Policlinico G Martino, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Defina+M%22">Defina M</searchLink>; Hematology Unit, Dipartimento Terapie Cellulari, Ematologia e Medicina di Laboratorio, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Farina+M%22">Farina M</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+S%22">Bernardi S</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy; CREA Laboratory (Hematological-Research AIL Centre), ASST-Spedali Civili Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Butturini+G%22">Butturini G</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Pellizzeri+S%22">Pellizzeri S</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Roccaro+AM%22">Roccaro AM</searchLink>; Clinical Trial Center. Translational Research and Phase I Unit, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+D%22">Russo D</searchLink>; Chair of Hematology, Department of Clinical and Experimental Sciences, University of Brescia, Unit of Blood Disease and Stem Cell Transplantation, ASST-Spedali Civili, Brescia, Italy.
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