Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
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| Title: | Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A. |
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| Authors: | Strilchuk AW; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Hur WS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Batty P; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., Sang Y; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Abrahams SR; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Yong ASM; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada., Leung J; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Silva LM; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Schroeder JA; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Nesbitt K; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., de Laat B; Synapse Research Institute, Maastricht 6217 KM, Netherlands., Moutsopoulos NM; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Bugge TH; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Shi Q; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Cullis PR; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Merricks EP; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wolberg AS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Flick MJ; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., Nichols TC; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kastrup CJ; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2024 Feb 21; Vol. 16 (735), pp. eadh0027. Date of Electronic Publication: 2024 Feb 21. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adh0027 |
