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Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.

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Title: Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Authors: Strilchuk AW; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Hur WS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Batty P; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., Sang Y; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Abrahams SR; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Yong ASM; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada., Leung J; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Silva LM; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Schroeder JA; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Nesbitt K; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., de Laat B; Synapse Research Institute, Maastricht 6217 KM, Netherlands., Moutsopoulos NM; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Bugge TH; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA., Shi Q; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Cullis PR; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada., Merricks EP; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wolberg AS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Flick MJ; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada., Nichols TC; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kastrup CJ; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Feb 21; Vol. 16 (735), pp. eadh0027. Date of Electronic Publication: 2024 Feb 21.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
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  Data: <searchLink fieldCode="AU" term="%22Strilchuk+AW%22">Strilchuk AW</searchLink>; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.<br /><searchLink fieldCode="AU" term="%22Hur+WS%22">Hur WS</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Batty+P%22">Batty P</searchLink>; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.<br /><searchLink fieldCode="AU" term="%22Sang+Y%22">Sang Y</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Abrahams+SR%22">Abrahams SR</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Yong+ASM%22">Yong ASM</searchLink>; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.<br /><searchLink fieldCode="AU" term="%22Leung+J%22">Leung J</searchLink>; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.<br /><searchLink fieldCode="AU" term="%22Silva+LM%22">Silva LM</searchLink>; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Schroeder+JA%22">Schroeder JA</searchLink>; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Nesbitt+K%22">Nesbitt K</searchLink>; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.<br /><searchLink fieldCode="AU" term="%22de+Laat+B%22">de Laat B</searchLink>; Synapse Research Institute, Maastricht 6217 KM, Netherlands.<br /><searchLink fieldCode="AU" term="%22Moutsopoulos+NM%22">Moutsopoulos NM</searchLink>; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bugge+TH%22">Bugge TH</searchLink>; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Cullis+PR%22">Cullis PR</searchLink>; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.<br /><searchLink fieldCode="AU" term="%22Merricks+EP%22">Merricks EP</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Wolberg+AS%22">Wolberg AS</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Flick+MJ%22">Flick MJ</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Lillicrap+D%22">Lillicrap D</searchLink>; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.<br /><searchLink fieldCode="AU" term="%22Nichols+TC%22">Nichols TC</searchLink>; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kastrup+CJ%22">Kastrup CJ</searchLink>; Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 2A1, Canada.; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Feb 21; Vol. 16 (735), pp. eadh0027. <i>Date of Electronic Publication: </i>2024 Feb 21.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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