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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.

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Title: Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
Authors: Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Patel SS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lo JH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cavnar AB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Babb LM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Gbur EF; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Patil P; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Colazo JM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sanchez VM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McCune JT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Ma J; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., DeJulius CR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lee LH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Rosch JC; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Allen RM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Stokes LD; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Hill JL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Cook RS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. craig.duvall@vanderbilt.edu.
Source: Nature communications [Nat Commun] 2024 Feb 21; Vol. 15 (1), pp. 1581. Date of Electronic Publication: 2024 Feb 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
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