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A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.

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Title: A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Authors: Aldous SG; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Smith EJ; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Landles C; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Osborne GF; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Cañibano-Pico M; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Nita IM; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Phillips J; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Zhang Y; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA., Jin B; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA., Hirst MB; Rancho BioSciences, San Diego, CA 92127, USA., Benn CL; LoQus23 Therapeutics, Riverside, Babraham Research Campus, Cambridge, CB22 3AT, UK., Bond BC; Prism Training and Consultancy Limited, St John's Innovation Centre, Cambridge, CB4 0WS, UK., Edelmann W; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA., Greene JR; Rancho BioSciences, San Diego, CA 92127, USA., Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Source: Brain : a journal of neurology [Brain] 2024 May 03; Vol. 147 (5), pp. 1784-1798.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
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  Data: <searchLink fieldCode="AU" term="%22Aldous+SG%22">Aldous SG</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Smith+EJ%22">Smith EJ</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Landles+C%22">Landles C</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Osborne+GF%22">Osborne GF</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Cañibano-Pico+M%22">Cañibano-Pico M</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Nita+IM%22">Nita IM</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Phillips+J%22">Phillips J</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Jin+B%22">Jin B</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Hirst+MB%22">Hirst MB</searchLink>; Rancho BioSciences, San Diego, CA 92127, USA.<br /><searchLink fieldCode="AU" term="%22Benn+CL%22">Benn CL</searchLink>; LoQus23 Therapeutics, Riverside, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Bond+BC%22">Bond BC</searchLink>; Prism Training and Consultancy Limited, St John's Innovation Centre, Cambridge, CB4 0WS, UK.<br /><searchLink fieldCode="AU" term="%22Edelmann+W%22">Edelmann W</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Greene+JR%22">Greene JR</searchLink>; Rancho BioSciences, San Diego, CA 92127, USA.<br /><searchLink fieldCode="AU" term="%22Bates+GP%22">Bates GP</searchLink>; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
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