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A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.

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Title: A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.
Authors: Noor NM; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lee JC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK; Department of Gastroenterology, UCL Institute of Liver and Digestive Diseases, Royal Free Hospital, London, UK., Bond S; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK., Dowling F; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brezina B; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Patel KV; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK., Ahmad T; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Banim PJ; Department of Gastroenterology, James Paget University Hospital, Great Yarmouth, UK., Berrill JW; Department of Gastroenterology, Royal Glamorgan Hospital, Llantrisant, UK., Cooney R; GI Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., De La Revilla Negro J; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., de Silva S; Department of Gastroenterology, The Dudley Group NHS Foundation Trust, Dudley, UK., Din S; Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK., Durai D; Department of Gastroenterology, Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff, UK., Gordon JN; Department of Gastroenterology, Royal Hampshire County Hospital, Winchester, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Johnson M; Gastroenterology Department, Luton and Dunstable University Hospital, Luton, UK., Kent AJ; Department of Gastroenterology, King's College Hospital NHS Foundation Trust, London, UK., Kok KB; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK., Moran GW; National Institute of Health Research Nottingham Biomedical Research Centre, University of Nottingham and Nottingham University Hospitals, Nottingham, UK., Mowat C; Department of Gastroenterology, Ninewells Hospital, Dundee, Scotland, UK., Patel P; Department of Gastroenterology, Epsom and St Helier University Hospitals, Carshalton, UK., Probert CS; Department of Gastroenterology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Raine T; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Saich R; Department of Gastroenterology, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Seward A; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK., Sharpstone D; Department of Gastroenterology, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK., Smith MA; Department of Gastroenterology, University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Subramanian S; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wiles A; Department of Gastroenterology, The Queen Elizabeth Hospital King's Lynn NHS Trust, King's Lynn, UK., Williams HRT; Department of Gastroenterology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK., van den Brink GR; Roche Innovation Center Basel, Roche, Basel, Basel-Stadt, Switzerland., Vermeire S; Department of Gastroenterology and Hepatology, Department of Chronic Diseases and Metabolism, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Jairath V; Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada., D'Haens GR; Department of Gastroenterology, Amsterdam University Medical Center, Amsterdam, Netherlands., McKinney EF; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Lyons PA; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Lindsay JO; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK., Kennedy NA; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Smith KGC; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Parkes M; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK. Electronic address: mp372@cam.ac.uk.
Corporate Authors: PROFILE Study Group
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 May; Vol. 9 (5), pp. 415-427. Date of Electronic Publication: 2024 Feb 22.
Publication Type: Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Noor+NM%22">Noor NM</searchLink>; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lee+JC%22">Lee JC</searchLink>; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK; Department of Gastroenterology, UCL Institute of Liver and Digestive Diseases, Royal Free Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Bond+S%22">Bond S</searchLink>; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dowling+F%22">Dowling F</searchLink>; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brezina+B%22">Brezina B</searchLink>; 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Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wiles+A%22">Wiles A</searchLink>; Department of Gastroenterology, The Queen Elizabeth Hospital King's Lynn NHS Trust, King's Lynn, UK.<br /><searchLink fieldCode="AU" term="%22Williams+HRT%22">Williams HRT</searchLink>; Department of Gastroenterology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+GR%22">van den Brink GR</searchLink>; Roche Innovation Center Basel, Roche, Basel, Basel-Stadt, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vermeire+S%22">Vermeire S</searchLink>; Department of Gastroenterology and Hepatology, Department of Chronic Diseases and Metabolism, University Hospitals Leuven, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jairath+V%22">Jairath V</searchLink>; Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22D'Haens+GR%22">D'Haens GR</searchLink>; 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