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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.

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Title: Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.
Authors: Bläsius K; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Ludwig L; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Knapp S; Institute of Biochemistry and Molecular Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Flaßhove C; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Sonnabend F; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Keller D; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Tacken N; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Gao X; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Kahveci-Türköz S; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Grannemann C; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Babendreyer A; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Adrain C; Patrick G Johnston Centre for Cancer Research, Queen's University, Belfast, Northern Ireland., Huth S; Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Baron JM; Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Ludwig A; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany., Düsterhöft S; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany. sduesterhoeft@ukaachen.de.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Feb 27; Vol. 81 (1), pp. 102. Date of Electronic Publication: 2024 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.
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  Data: <searchLink fieldCode="AU" term="%22Bläsius+K%22">Bläsius K</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig+L%22">Ludwig L</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Institute of Biochemistry and Molecular Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Flaßhove+C%22">Flaßhove C</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Sonnabend+F%22">Sonnabend F</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+D%22">Keller D</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Tacken+N%22">Tacken N</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kahveci-Türköz+S%22">Kahveci-Türköz S</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Grannemann+C%22">Grannemann C</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Babendreyer+A%22">Babendreyer A</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Adrain+C%22">Adrain C</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University, Belfast, Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Huth+S%22">Huth S</searchLink>; Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Baron+JM%22">Baron JM</searchLink>; Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig+A%22">Ludwig A</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Düsterhöft+S%22">Düsterhöft S</searchLink>; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany. sduesterhoeft@ukaachen.de.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2024 Feb 27; Vol. 81 (1), pp. 102. <i>Date of Electronic Publication: </i>2024 Feb 27.
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