Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity. - Bläsius K; Ludwig L; Knapp S; Flaßhove C; Sonnabend F; Keller D; Tacken N; Gao X; Kahveci-Türköz S; Grannemann C; Babendreyer A; Adrain C; et al. (Cellular and molecular life sciences : CMLS, 2024)