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Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer.

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Title: Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer.
Authors: Bacci M; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Lorito N; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Smiriglia A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Subbiani A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Bonechi F; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Comito G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Morriset L; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France., El Botty R; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France., Benelli M; Department of Medical Oncology, Azienda USL Toscana Centro, Hospital of Prato, Via Suor Niccolina Infermiera 20, 59100 Prato, Italy., López-Velazco JI; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain., Caffarel MM; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain.; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009 Bilbao, Spain., Urruticoechea A; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Paseo Dr Begiristain 121, 20014 San Sebastian, Spain., Sflomos G; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Malorni L; Department of Medical Oncology, Azienda USL Toscana Centro, Hospital of Prato, Via Suor Niccolina Infermiera 20, 59100 Prato, Italy., Corsini M; Department of Molecular and Translational Medicine, University of Brescia, Via Branze 39, 25123 Brescia, Italy., Ippolito L; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Giannoni E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Meattini I; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy., Matafora V; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy., Havas K; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy., Bachi A; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy., Chiarugi P; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Marangoni E; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France., Morandi A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Source: Science translational medicine [Sci Transl Med] 2024 Feb 28; Vol. 16 (736), pp. eadf9874. Date of Electronic Publication: 2024 Feb 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER<superscript>+</superscript> breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Bacci+M%22">Bacci M</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Lorito+N%22">Lorito N</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Smiriglia+A%22">Smiriglia A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Subbiani+A%22">Subbiani A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bonechi+F%22">Bonechi F</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Comito+G%22">Comito G</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Morriset+L%22">Morriset L</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Botty+R%22">El Botty R</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France.<br /><searchLink fieldCode="AU" term="%22Benelli+M%22">Benelli M</searchLink>; Department of Medical Oncology, Azienda USL Toscana Centro, Hospital of Prato, Via Suor Niccolina Infermiera 20, 59100 Prato, Italy.<br /><searchLink fieldCode="AU" term="%22López-Velazco+JI%22">López-Velazco JI</searchLink>; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Caffarel+MM%22">Caffarel MM</searchLink>; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain.; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009 Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Urruticoechea+A%22">Urruticoechea A</searchLink>; Biodonostia Health Research Institute, Paseo Dr Begiristain s/n, 20014 San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Paseo Dr Begiristain 121, 20014 San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Sflomos+G%22">Sflomos G</searchLink>; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Malorni+L%22">Malorni L</searchLink>; Department of Medical Oncology, Azienda USL Toscana Centro, Hospital of Prato, Via Suor Niccolina Infermiera 20, 59100 Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Corsini+M%22">Corsini M</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Via Branze 39, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ippolito+L%22">Ippolito L</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Giannoni+E%22">Giannoni E</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Meattini+I%22">Meattini I</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Matafora+V%22">Matafora V</searchLink>; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Havas+K%22">Havas K</searchLink>; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bachi+A%22">Bachi A</searchLink>; IFOM ETS-AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Chiarugi+P%22">Chiarugi P</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Marangoni+E%22">Marangoni E</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, 26 rue d'Ulm, 75005 Paris, France.<br /><searchLink fieldCode="AU" term="%22Morandi+A%22">Morandi A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
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