Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.
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| Title: | Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. |
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| Authors: | Blumel L; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bernardi F; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Picard D; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Diaz JT; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Jepsen VH; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Hasselmann R; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Schliehe-Diecks J; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bartl J; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf, Germany; Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg, Hamburg., Qin N; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Bornhauser B; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Bhatia S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Marovka B; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Marsaud V; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Dingli F; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris., Loew D; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris., Stanulla M; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover., Bourqin JP; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Remke M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf., Ayrault O; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay., Fischer U; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf. ute.fischer@med.uni-duesseldorf.de. |
| Source: | Haematologica [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2290-2296. Date of Electronic Publication: 2024 Jul 01. |
| Publication Type: | Letter; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38426288 AccessLevel: 2 PubType: Report PubTypeId: report PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Blumel+L%22">Blumel L</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Bernardi+F%22">Bernardi F</searchLink>; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.<br /><searchLink fieldCode="AU" term="%22Picard+D%22">Picard D</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Diaz+JT%22">Diaz JT</searchLink>; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.<br /><searchLink fieldCode="AU" term="%22Jepsen+VH%22">Jepsen VH</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Hasselmann+R%22">Hasselmann R</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Schliehe-Diecks+J%22">Schliehe-Diecks J</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Bartl+J%22">Bartl J</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf, Germany; Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg, Hamburg.<br /><searchLink fieldCode="AU" term="%22Qin+N%22">Qin N</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich.<br /><searchLink fieldCode="AU" term="%22Bhatia+S%22">Bhatia S</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Marovka+B%22">Marovka B</searchLink>; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich.<br /><searchLink fieldCode="AU" term="%22Marsaud+V%22">Marsaud V</searchLink>; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.<br /><searchLink fieldCode="AU" term="%22Dingli+F%22">Dingli F</searchLink>; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris.<br /><searchLink fieldCode="AU" term="%22Loew+D%22">Loew D</searchLink>; Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris.<br /><searchLink fieldCode="AU" term="%22Stanulla+M%22">Stanulla M</searchLink>; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover.<br /><searchLink fieldCode="AU" term="%22Bourqin+JP%22">Bourqin JP</searchLink>; Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich.<br /><searchLink fieldCode="AU" term="%22Borkhardt+A%22">Borkhardt A</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Remke+M%22">Remke M</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.<br /><searchLink fieldCode="AU" term="%22Ayrault+O%22">Ayrault O</searchLink>; Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.<br /><searchLink fieldCode="AU" term="%22Fischer+U%22">Fischer U</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf. ute.fischer@med.uni-duesseldorf.de. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2290-2296. <i>Date of Electronic Publication: </i>2024 Jul 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Letter; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3324/haematol.2023.283928 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2290 Titles: – TitleFull: Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Blumel L – PersonEntity: Name: NameFull: Bernardi F – PersonEntity: Name: NameFull: Picard D – PersonEntity: Name: NameFull: Diaz JT – PersonEntity: Name: NameFull: Jepsen VH – PersonEntity: Name: NameFull: Hasselmann R – PersonEntity: Name: NameFull: Schliehe-Diecks J – PersonEntity: Name: NameFull: Bartl J – PersonEntity: Name: NameFull: Qin N – PersonEntity: Name: NameFull: Bornhauser B – PersonEntity: Name: NameFull: Bhatia S – PersonEntity: Name: NameFull: Marovka B – PersonEntity: Name: NameFull: Marsaud V – PersonEntity: Name: NameFull: Dingli F – PersonEntity: Name: NameFull: Loew D – PersonEntity: Name: NameFull: Stanulla M – PersonEntity: Name: NameFull: Bourqin JP – PersonEntity: Name: NameFull: Borkhardt A – PersonEntity: Name: NameFull: Remke M – PersonEntity: Name: NameFull: Ayrault O – PersonEntity: Name: NameFull: Fischer U IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2024 Jul 01 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1592-8721 Numbering: – Type: volume Value: 109 – Type: issue Value: 7 Titles: – TitleFull: Haematologica Type: main |
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