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A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss.

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Title: A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss.
Authors: Schilder AGM; National Institute for Health Research University College London Hospitals Biomedical Research Centre, London, UK.; Ear Institute, University College London, London, UK.; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, London, UK., Wolpert S; Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany. stephan.wolpert@med.uni-tuebingen.de., Saeed S; National Institute for Health Research University College London Hospitals Biomedical Research Centre, London, UK.; Ear Institute, University College London, London, UK.; Royal National ENT and Eastman Dental Hospitals, University College London Hospitals Trust, London, UK., Middelink LM; Middelinc, Utrecht, the Netherlands., Edge ASB; Department of Otolaryngology, Harvard Medical School, Boston, USA., Blackshaw H; National Institute for Health Research University College London Hospitals Biomedical Research Centre, London, UK.; Ear Institute, University College London, London, UK., Pastiadis K; 1st Department of Otolaryngology, Hippocration Hospital Athens, National & Kapodistrian University of Athens, Athens, Greece., Bibas AG; 1st Department of Otolaryngology, Hippocration Hospital Athens, National & Kapodistrian University of Athens, Athens, Greece.
Corporate Authors: REGAIN Consortium
Source: Nature communications [Nat Commun] 2024 Mar 01; Vol. 15 (1), pp. 1896. Date of Electronic Publication: 2024 Mar 01.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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