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SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.

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Title: SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.
Authors: Bhuiyan MIH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA., Habib K; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA., Sultan MT; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA., Chen F; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Jahan I; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Weng Z; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rahman MS; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA., Islam R; Nostrum Hospital, Dhaka, Bangladesh., Foley LM; Animal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hitchens TK; Animal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Deng X; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Canna SW; Department of Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Sun D; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA., Cao G; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14654.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.
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  Data: <searchLink fieldCode="AU" term="%22Bhuiyan+MIH%22">Bhuiyan MIH</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Habib+K%22">Habib K</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Sultan+MT%22">Sultan MT</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Jahan+I%22">Jahan I</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Weng+Z%22">Weng Z</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+MS%22">Rahman MS</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Islam+R%22">Islam R</searchLink>; Nostrum Hospital, Dhaka, Bangladesh.<br /><searchLink fieldCode="AU" term="%22Foley+LM%22">Foley LM</searchLink>; Animal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hitchens+TK%22">Hitchens TK</searchLink>; Animal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Canna+SW%22">Canna SW</searchLink>; Department of Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Cao+G%22">Cao G</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Veterans Affairs Pittsburgh Health Care System Pittsburgh Healthcare System, Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, USA.
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