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Genome-wide characterization of circulating metabolic biomarkers.

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Title: Genome-wide characterization of circulating metabolic biomarkers.
Authors: Karjalainen MK; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland. minna.k.karjalainen@oulu.fi.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. minna.k.karjalainen@oulu.fi.; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland. minna.k.karjalainen@oulu.fi., Karthikeyan S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Oliver-Williams C; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Public Health Specialty Training Programme, Cambridge, UK., Sliz E; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland., Allara E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Fung WT; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Surendran P; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Kristiansson K; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Goodwin M; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Hughes DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Nanjing Medical University, Jiangsu, China., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Neville MJ; NIHR Oxford Biomedical Research Centre, OUHFT Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., van Zuydam NR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Demirkan A; Surrey Institute for People-Centred AI, University of Surrey, Guildford, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Kartsonaki C; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hagenbeek FA; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Pool R; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., van Meurs J; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Haller T; Institute of Genomics, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Kähönen M; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Mishra PP; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Joshi PK; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Macdonald-Dunlop E; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Zierer J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Acar IE; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Hoyng CB; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Lechanteur YTE; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Kurilshikov A; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Zhernakova A; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Beekman M; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., van den Akker EB; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.; Center for Computational Biology, Leiden University Medical Center, Leiden, The Netherlands.; The Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., Kolcic I; Department of Public Health, School of Medicine, University of Split, Split, Croatia., Polasek O; Department of Public Health, School of Medicine, University of Split, Split, Croatia., Rudan I; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Asselbergs FW; Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Fu J; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., den Hollander AI; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.; Genomics Research Center, Abbvie, Cambridge, MA, USA., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Wilson JF; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Lehtimäki T; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; InFLAMES Research Flagship, University of Turku, Turku, Finland., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Sattar N; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Willems van Dijk K; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Karpe F; NIHR Oxford Biomedical Research Centre, OUHFT Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Järvelin MR; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Perola M; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., van Duijn C; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Slagboom PE; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Ala-Korpela M; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Kettunen J; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Corporate Authors: China Kadoorie Biobank Collaborative Group, Estonian Biobank Research Team, FinnGen
Source: Nature [Nature] 2024 Apr; Vol. 628 (8006), pp. 130-138. Date of Electronic Publication: 2024 Mar 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-wide characterization of circulating metabolic biomarkers.
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  Label: Authors
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Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Allara+E%22">Allara E</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fung+WT%22">Fung WT</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Surendran+P%22">Surendran P</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Jousilahti+P%22">Jousilahti P</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kristiansson+K%22">Kristiansson K</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Salomaa+V%22">Salomaa V</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Goodwin+M%22">Goodwin M</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Hughes+DA%22">Hughes DA</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fernandes+Silva+L%22">Fernandes Silva L</searchLink>; 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Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22de+Mutsert+R%22">de Mutsert R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Li-Gao+R%22">Li-Gao R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mook-Kanamori+DO%22">Mook-Kanamori DO</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Demirkan+A%22">Demirkan A</searchLink>; Surrey Institute for People-Centred AI, University of Surrey, Guildford, UK.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Noordam+R%22">Noordam R</searchLink>; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Trompet+S%22">Trompet S</searchLink>; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kartsonaki+C%22">Kartsonaki C</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hagenbeek+FA%22">Hagenbeek FA</searchLink>; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Hottenga+JJ%22">Hottenga JJ</searchLink>; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pool+R%22">Pool R</searchLink>; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ikram+MA%22">Ikram MA</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Meurs+J%22">van Meurs J</searchLink>; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haller+T%22">Haller T</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Milaneschi+Y%22">Milaneschi Y</searchLink>; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kähönen+M%22">Kähönen M</searchLink>; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Mishra+PP%22">Mishra PP</searchLink>; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Joshi+PK%22">Joshi PK</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Macdonald-Dunlop+E%22">Macdonald-Dunlop E</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Mangino+M%22">Mangino M</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Zierer+J%22">Zierer J</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Acar+IE%22">Acar IE</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoyng+CB%22">Hoyng CB</searchLink>; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lechanteur+YTE%22">Lechanteur YTE</searchLink>; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Franke+L%22">Franke L</searchLink>; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kurilshikov+A%22">Kurilshikov A</searchLink>; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhernakova+A%22">Zhernakova A</searchLink>; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beekman+M%22">Beekman M</searchLink>; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Akker+EB%22">van den Akker EB</searchLink>; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.; Center for Computational Biology, Leiden University Medical Center, Leiden, The Netherlands.; The Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kolcic+I%22">Kolcic I</searchLink>; Department of Public Health, School of Medicine, University of Split, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Polasek+O%22">Polasek O</searchLink>; Department of Public Health, School of Medicine, University of Split, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Rudan+I%22">Rudan I</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Waldenberger+M%22">Waldenberger M</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Asselbergs+FW%22">Asselbergs FW</searchLink>; Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22den+Hollander+AI%22">den Hollander AI</searchLink>; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.; Genomics Research Center, Abbvie, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Menni+C%22">Menni C</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Spector+TD%22">Spector TD</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+JF%22">Wilson JF</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Raitakari+OT%22">Raitakari OT</searchLink>; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; InFLAMES Research Flagship, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Penninx+BWJH%22">Penninx BWJH</searchLink>; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Walters+RG%22">Walters RG</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jukema+JW%22">Jukema JW</searchLink>; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sattar+N%22">Sattar N</searchLink>; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ghanbari+M%22">Ghanbari M</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Willems+van+Dijk+K%22">Willems van Dijk K</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Karpe+F%22">Karpe F</searchLink>; NIHR Oxford Biomedical Research Centre, OUHFT Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Järvelin+MR%22">Järvelin MR</searchLink>; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Timpson+NJ%22">Timpson NJ</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Perola+M%22">Perola M</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Kooner+JS%22">Kooner JS</searchLink>; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chambers+JC%22">Chambers JC</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22van+Duijn+C%22">van Duijn C</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Slagboom+PE%22">Slagboom PE</searchLink>; Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boomsma+DI%22">Boomsma DI</searchLink>; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Danesh+J%22">Danesh J</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Ala-Korpela+M%22">Ala-Korpela M</searchLink>; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Butterworth+AS%22">Butterworth AS</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kettunen+J%22">Kettunen J</searchLink>; Systems Epidemiology, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2024 Apr; Vol. 628 (8006), pp. 130-138. <i>Date of Electronic Publication: </i>2024 Mar 06.
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