Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.

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Title: Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.
Authors: van Veggel L; Department of Neuroscience, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Hasselt, Belgium.; Department of Psychiatry and Neuropsychology, Division of Translational Neuroscience, European Graduate School of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands.; University MS Center (UMSC), 3900 Hasselt-Pelt, Belgium., Mocking TAM; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Sijben HJ; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Liu R; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Gorostiola González M; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Dilweg MA; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Royakkers J; Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 Maastricht, The Netherlands., Li A; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K., Kumar V; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K., Dong YY; Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 7BN Oxford, U.K., Bullock A; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K., Sauer DB; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K., Diliën H; Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 Maastricht, The Netherlands., van Westen GJP; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands., Schreiber R; Section of Psychopharmacology, Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands., Heitman LH; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.; Oncode Institute, Einsteinweg 55, 2333 Leiden, The Netherlands., Vanmierlo T; Department of Neuroscience, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Hasselt, Belgium.; Department of Psychiatry and Neuropsychology, Division of Translational Neuroscience, European Graduate School of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands.; University MS Center (UMSC), 3900 Hasselt-Pelt, Belgium.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Apr 03; Vol. 15 (7), pp. 1424-1431. Date of Electronic Publication: 2024 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
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  Data: Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays.
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  Data: <searchLink fieldCode="AU" term="%22van+Veggel+L%22">van Veggel L</searchLink>; Department of Neuroscience, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Hasselt, Belgium.; Department of Psychiatry and Neuropsychology, Division of Translational Neuroscience, European Graduate School of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands.; University MS Center (UMSC), 3900 Hasselt-Pelt, Belgium.<br /><searchLink fieldCode="AU" term="%22Mocking+TAM%22">Mocking TAM</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sijben+HJ%22">Sijben HJ</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gorostiola+González+M%22">Gorostiola González M</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dilweg+MA%22">Dilweg MA</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Royakkers+J%22">Royakkers J</searchLink>; Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Kumar+V%22">Kumar V</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Dong+YY%22">Dong YY</searchLink>; Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 7BN Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Bullock+A%22">Bullock A</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Sauer+DB%22">Sauer DB</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K.<br /><searchLink fieldCode="AU" term="%22Diliën+H%22">Diliën H</searchLink>; Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Westen+GJP%22">van Westen GJP</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schreiber+R%22">Schreiber R</searchLink>; Section of Psychopharmacology, Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heitman+LH%22">Heitman LH</searchLink>; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands.; Oncode Institute, Einsteinweg 55, 2333 Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vanmierlo+T%22">Vanmierlo T</searchLink>; Department of Neuroscience, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Hasselt, Belgium.; Department of Psychiatry and Neuropsychology, Division of Translational Neuroscience, European Graduate School of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands.; University MS Center (UMSC), 3900 Hasselt-Pelt, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101525337%22">ACS chemical neuroscience</searchLink> [ACS Chem Neurosci] 2024 Apr 03; Vol. 15 (7), pp. 1424-1431. <i>Date of Electronic Publication: </i>2024 Mar 13.
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