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Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.

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Title: Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
Authors: von Mässenhausen A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany., Schlecht MN; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Beer K; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Maremonti F; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Tonnus W; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Belavgeni A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Gavali S; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Flade K; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Riley JS; Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK.; Biocenter Innsbruck (CCB), Medical University Innsbruck, Division of Developmental Immunology, Innrain 80, 6020 Innsbruck, Austria., Zamora Gonzalez N; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Brucker A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Becker JN; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Tmava M; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Meyer C; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Peitzsch M; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Hugo C; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Gembardt F; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany., Angeli JPF; Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Würzburg, 97080 Würzburg, Germany., Bornstein SR; Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Diabetes and Nutritional Sciences, King's College London, London, UK.; Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Dresden, Germany.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Tait SWG; Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK., Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Source: Science advances [Sci Adv] 2024 Mar 15; Vol. 10 (11), pp. eadk7329. Date of Electronic Publication: 2024 Mar 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22von+Mässenhausen+A%22">von Mässenhausen A</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schlecht+MN%22">Schlecht MN</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Beer+K%22">Beer K</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Maremonti+F%22">Maremonti F</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Tonnus+W%22">Tonnus W</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Belavgeni+A%22">Belavgeni A</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Gavali+S%22">Gavali S</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Flade+K%22">Flade K</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Riley+JS%22">Riley JS</searchLink>; Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK.; Biocenter Innsbruck (CCB), Medical University Innsbruck, Division of Developmental Immunology, Innrain 80, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Zamora+Gonzalez+N%22">Zamora Gonzalez N</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Brucker+A%22">Brucker A</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+JN%22">Becker JN</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Tmava+M%22">Tmava M</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+C%22">Meyer C</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Peitzsch+M%22">Peitzsch M</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hugo+C%22">Hugo C</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Gembardt+F%22">Gembardt F</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Angeli+JPF%22">Angeli JPF</searchLink>; Rudolf Virchow Center for Integrative and Translational Bioimaging, Chair of Translational Cell Biology, University of Würzburg, 97080 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bornstein+SR%22">Bornstein SR</searchLink>; Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.; Diabetes and Nutritional Sciences, King's College London, London, UK.; Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Dresden, Germany.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tait+SWG%22">Tait SWG</searchLink>; Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Linkermann+A%22">Linkermann A</searchLink>; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, 01307 Dresden, Germany.; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2024 Mar 15; Vol. 10 (11), pp. eadk7329. <i>Date of Electronic Publication: </i>2024 Mar 15.
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