Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.

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Title: Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.
Authors: D'Ambrosio A; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; SEMM, University of Milan, 20142 Milan, Italy., Bressan D; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Ferracci E; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Carbone F; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy., Mulè P; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy., Rossi F; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy., Barbieri C; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy., Sorrenti E; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Fiaccadori G; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Detone T; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy., Vezzoli E; Department of Biomedical sciences for Health, University of Milan, 20133 Milan, Italy., Bianchi S; Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy., Sartori C; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy., Corso S; Department of Oncology, University of Torino, 10060 Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Bertalot G; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.; Centre for Medical Sciences-CISMed, University of Trento, 38122 Trento, Italy., Falqui A; Department of Physics, University of Milan, 20133 Milan, Italy., Barbareschi M; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.; Centre for Medical Sciences-CISMed, University of Trento, 38122 Trento, Italy., Romanel A; Laboratory of Bioinformatics and Computational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Pasini D; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.; Department of Health Sciences, University of Milan, 20142 Milan, Italy., Chiacchiera F; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
Source: Science advances [Sci Adv] 2024 Mar 15; Vol. 10 (11), pp. eadh4435. Date of Electronic Publication: 2024 Mar 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.
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  Data: <searchLink fieldCode="AU" term="%22D'Ambrosio+A%22">D'Ambrosio A</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.; SEMM, University of Milan, 20142 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bressan+D%22">Bressan D</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Ferracci+E%22">Ferracci E</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Carbone+F%22">Carbone F</searchLink>; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Mulè+P%22">Mulè P</searchLink>; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+F%22">Rossi F</searchLink>; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Barbieri+C%22">Barbieri C</searchLink>; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sorrenti+E%22">Sorrenti E</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Fiaccadori+G%22">Fiaccadori G</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Detone+T%22">Detone T</searchLink>; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Vezzoli+E%22">Vezzoli E</searchLink>; Department of Biomedical sciences for Health, University of Milan, 20133 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchi+S%22">Bianchi S</searchLink>; Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sartori+C%22">Sartori C</searchLink>; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Corso+S%22">Corso S</searchLink>; Department of Oncology, University of Torino, 10060 Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Fukuda+A%22">Fukuda A</searchLink>; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Bertalot+G%22">Bertalot G</searchLink>; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.; Centre for Medical Sciences-CISMed, University of Trento, 38122 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Falqui+A%22">Falqui A</searchLink>; Department of Physics, University of Milan, 20133 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Barbareschi+M%22">Barbareschi M</searchLink>; Unità Operativa Multizonale di Anatomia Patologica, APSS, 38122 Trento, Italy.; Centre for Medical Sciences-CISMed, University of Trento, 38122 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Romanel+A%22">Romanel A</searchLink>; Laboratory of Bioinformatics and Computational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Pasini+D%22">Pasini D</searchLink>; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.; Department of Health Sciences, University of Milan, 20142 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Chiacchiera+F%22">Chiacchiera F</searchLink>; Laboratory of stem cells and cancer genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
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