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Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler.

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Title: Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler.
Authors: Kirsanov RS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khailova LS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Rokitskaya TI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Lyamzaev KG; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.; The 'Russian Clinical Research Center for Gerontology' of the Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, 117997 Moscow, Russia., Panteleeva AA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Nazarov PA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Firsov AM; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Iaubasarova IR; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Korshunova GA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Kotova EA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Antonenko YN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Source: ACS omega [ACS Omega] 2024 Feb 29; Vol. 9 (10), pp. 11551-11561. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
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  Data: Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler.
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  Data: <searchLink fieldCode="AU" term="%22Kirsanov+RS%22">Kirsanov RS</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Khailova+LS%22">Khailova LS</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Rokitskaya+TI%22">Rokitskaya TI</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Lyamzaev+KG%22">Lyamzaev KG</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.; The 'Russian Clinical Research Center for Gerontology' of the Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Panteleeva+AA%22">Panteleeva AA</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Nazarov+PA%22">Nazarov PA</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Firsov+AM%22">Firsov AM</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Iaubasarova+IR%22">Iaubasarova IR</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Korshunova+GA%22">Korshunova GA</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Kotova+EA%22">Kotova EA</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Antonenko+YN%22">Antonenko YN</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
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  Data: <searchLink fieldCode="JN" term="%22101691658%22">ACS omega</searchLink> [ACS Omega] 2024 Feb 29; Vol. 9 (10), pp. 11551-11561. <i>Date of Electronic Publication: </i>2024 Feb 29 (<i>Print Publication: </i>2024).
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