Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice.

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Title: Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice.
Authors: Preite NW; Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil., Borges BM; Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil., Kaminski VL; Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil., Ayupe MC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Gonçalves LM; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Dos Santos BV; Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil., Fonseca DLM; Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil., Filgueiras IS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Salgado CL; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Muxel SM; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Cabral-Marques O; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil.; Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine (USP), São Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.; Network of Immunity in Infection, Malignancy, Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), São Paulo, Brazil., da Fonseca DM; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil., Loures FV; Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil., Calich VLG; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Source: Frontiers in immunology [Front Immunol] 2024 Mar 04; Vol. 15, pp. 1347318. Date of Electronic Publication: 2024 Mar 04 (Print Publication: 2024).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1664-3224
DOI:10.3389/fimmu.2024.1347318