CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.
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| Title: | CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans. |
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| Authors: | White CW; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia., Platt S; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK., Kilpatrick LE; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Dale N; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia., Abhayawardana RS; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia., Dekkers S; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Kindon ND; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Kellam B; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Stocks MJ; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Pfleger KDG; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia., Hill SJ; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK. |
| Source: | Science signaling [Sci Signal] 2024 Mar 19; Vol. 17 (828), pp. eabl3758. Date of Electronic Publication: 2024 Mar 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1937-9145 |
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| DOI: | 10.1126/scisignal.abl3758 |
