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CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.

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Title: CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.
Authors: White CW; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia., Platt S; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK., Kilpatrick LE; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Dale N; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia., Abhayawardana RS; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia., Dekkers S; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Kindon ND; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Kellam B; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Stocks MJ; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Pfleger KDG; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia., Hill SJ; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.
Source: Science signaling [Sci Signal] 2024 Mar 19; Vol. 17 (828), pp. eabl3758. Date of Electronic Publication: 2024 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.
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  Data: <searchLink fieldCode="AU" term="%22White+CW%22">White CW</searchLink>; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Platt+S%22">Platt S</searchLink>; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.<br /><searchLink fieldCode="AU" term="%22Kilpatrick+LE%22">Kilpatrick LE</searchLink>; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Dale+N%22">Dale N</searchLink>; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Abhayawardana+RS%22">Abhayawardana RS</searchLink>; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dekkers+S%22">Dekkers S</searchLink>; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Kindon+ND%22">Kindon ND</searchLink>; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Kellam+B%22">Kellam B</searchLink>; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Stocks+MJ%22">Stocks MJ</searchLink>; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Pfleger+KDG%22">Pfleger KDG</searchLink>; Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, Victoria, Australia.; Dimerix Limited, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hill+SJ%22">Hill SJ</searchLink>; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2024 Mar 19; Vol. 17 (828), pp. eabl3758. <i>Date of Electronic Publication: </i>2024 Mar 19.
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