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Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.

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Title: Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
Authors: Ţînţaş ML; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr., Peauger L; VFP Therapies 15 rue François Couperin 76000 Rouen France., Barré A; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr., Papamicaël C; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr., Besson T; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr., Sopkovà-de Oliveira Santos J; UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Médicament de Normandie), Normandie Univ. Bd Becquerel F-14032 Caen France., Gembus V; VFP Therapies 15 rue François Couperin 76000 Rouen France., Levacher V; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.
Source: RSC medicinal chemistry [RSC Med Chem] 2024 Feb 20; Vol. 15 (3), pp. 963-980. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
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  Data: <searchLink fieldCode="AU" term="%22Ţînţaş+ML%22">Ţînţaş ML</searchLink>; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.<br /><searchLink fieldCode="AU" term="%22Peauger+L%22">Peauger L</searchLink>; VFP Therapies 15 rue François Couperin 76000 Rouen France.<br /><searchLink fieldCode="AU" term="%22Barré+A%22">Barré A</searchLink>; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.<br /><searchLink fieldCode="AU" term="%22Papamicaël+C%22">Papamicaël C</searchLink>; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.<br /><searchLink fieldCode="AU" term="%22Besson+T%22">Besson T</searchLink>; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.<br /><searchLink fieldCode="AU" term="%22Sopkovà-de+Oliveira+Santos+J%22">Sopkovà-de Oliveira Santos J</searchLink>; UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Médicament de Normandie), Normandie Univ. Bd Becquerel F-14032 Caen France.<br /><searchLink fieldCode="AU" term="%22Gembus+V%22">Gembus V</searchLink>; VFP Therapies 15 rue François Couperin 76000 Rouen France.<br /><searchLink fieldCode="AU" term="%22Levacher+V%22">Levacher V</searchLink>; INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ INC3M FR 3038 F-76000 Rouen France vincent.levacher@insa-rouen.fr.
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  Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2024 Feb 20; Vol. 15 (3), pp. 963-980. <i>Date of Electronic Publication: </i>2024 Feb 20 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2024 Feb 20
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