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High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS.

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Title: High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS.
Authors: Jouvenot G; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France., Courbon G; Department of Neurology, University Hospital of Rennes, Rennes, France., Lefort M; University of Rennes, EHESP, CNRS, INSERM, Arènes-UMR 6051, RSMS (Recherche sur les Services et Management en Santé)-U 1309, Rennes, France., Rollot F; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France., Casey R; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France., Le Page E; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France., Michel L; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France., Edan G; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France., de Seze J; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France., Kremer L; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France., Bigaut K; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France., Vukusic S; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France., Mathey G; Department of Neurology, Nancy University Hospital, Nancy, France.; Université de Lorraine, APEMAC, Nancy, France., Ciron J; CRC-SEP, Department of Neurology, CHU de Toulouse, Toulouse, France., Ruet A; Department of Neurology, CHU de Bordeaux, CIC Bordeaux CIC1401, Bordeaux, France., Maillart E; Département de Neurologie, Hôpital Pitié-Salpêtrière, APHP, Centre de Ressources et de Compétences SEP, Paris, France., Labauge P; MS Unit, CHU de Montpellier, Montpellier, France., Zephir H; CRC-SEP Lille, CHU Lille, Lille, France., Papeix C; Department of Neurology, Fondation Rothschild, Paris, France., Defer G; Department of Neurology, MS Expert Centre, CHU de Caen, Caen, France., Lebrun-Frenay C; Neurology, UR2CA-URRIS, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France., Moreau T; Department of Neurology, CHU de Dijon, Dijon, France., Laplaud DA; Department of Neurology, CHU de Nantes, Nantes, France.; Nantes Université, CHU Nantes, INSERM, CIC 14131413, Center for Research in Translational Immunology, UMR 1064, Nantes, France., Berger E; Service de Neurologie, CHU de Besançon, Besançon, France., Stankoff B; Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France., Clavelou P; Department of Neurology, CHU Clermont-Ferrand, Clermont-Ferrand, France., Thouvenot E; Department of Neurology, Nimes University Hospital, Nimes, France., Heinzlef O; Hôpital de Poissy, Department of Neurology, Poissy, France., Pelletier J; Service de Neurologie, APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Marseille, France., Al-Khedr A; CHU d'Amiens, Department of Neurology, Amiens, France., Casez O; CHU Grenoble Alpes, Department of Neurology, Neurology MS Clinic Grenoble, Grenoble Alpes University Hospital, Grenoble, France., Bourre B; CHU de Rouen, Department of Neurology, Rouen, France., Cabre P; Department of Neurology, CHU de la Martinique, Fort-de-France, France., Wahab A; Department of Neurology, APHP, Hôpital Henri Mondor, Créteil, France., Magy L; Department of Neurology, CHU de Limoges, Hôpital Dupuytren, Limoges, France., Camdessanché JP; Department of Neurology, CHU de Saint-Étienne, Hôpital Nord, Saint-Étienne, France., Doghri I; Department of Neurology, CHU de Tours, Hôpital Bretonneau, Tours, France., Moulin S; Department of Neurology, CHU de Reims, CRC-SEP, Reims, France., Ben-Nasr H; Hôpital Sud Francilien, Department of Neurology, Corbeil-Essonnes, France., Labeyrie C; Department of Neurology, CHU Bicêtre, Le Kremlin-Bicêtre, France., Hankiewicz K; Department of Neurology, Hôpital Pierre Delafontaine, Centre Hospitalier de Saint-Denis, Saint-Denis, France., Neau JP; Department of Neurology, CHU La Milétrie, Hôpital Jean Bernard, Poitiers, France., Pottier C; Department of Neurology, CH de Pontoise, Hôpital René Dubos, Pontoise, France., Nifle C; Departement of Neurology, Centre Hospitalier de Versailles, Le Chesnay, France., Collongues N; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.; Department of Pharmacology, Addictology, Toxicology and Therapeutics, Strasbourg University, Strasbourg, France., Kerbrat A; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France.; Empenn U1228, University of Rennes, Inria, CNRS, INSERM, IRISA UMR 6074, Rennes, France.
Corporate Authors: OFSEP Investigators
Source: JAMA neurology [JAMA Neurol] 2024 May 01; Vol. 81 (5), pp. 490-498.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Observational Study; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older With Nonactive MS.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Jouvenot+G%22">Jouvenot G</searchLink>; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Courbon+G%22">Courbon G</searchLink>; Department of Neurology, University Hospital of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Lefort+M%22">Lefort M</searchLink>; University of Rennes, EHESP, CNRS, INSERM, Arènes-UMR 6051, RSMS (Recherche sur les Services et Management en Santé)-U 1309, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Rollot+F%22">Rollot F</searchLink>; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France.<br /><searchLink fieldCode="AU" term="%22Casey+R%22">Casey R</searchLink>; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France.<br /><searchLink fieldCode="AU" term="%22Le+Page+E%22">Le Page E</searchLink>; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Michel+L%22">Michel L</searchLink>; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Edan+G%22">Edan G</searchLink>; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22de+Seze+J%22">de Seze J</searchLink>; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Kremer+L%22">Kremer L</searchLink>; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Bigaut+K%22">Bigaut K</searchLink>; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Vukusic+S%22">Vukusic S</searchLink>; Université de Lyon, Université Claude Bernard, Lyon, France.; Department of Neurology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Bron, France.; Centre de Recherche en Neurosciences de Lyon, Observatoire Français de La Sclérose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France.; Eugène Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France.<br /><searchLink fieldCode="AU" term="%22Mathey+G%22">Mathey G</searchLink>; Department of Neurology, Nancy University Hospital, Nancy, France.; Université de Lorraine, APEMAC, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Ciron+J%22">Ciron J</searchLink>; CRC-SEP, Department of Neurology, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Ruet+A%22">Ruet A</searchLink>; Department of Neurology, CHU de Bordeaux, CIC Bordeaux CIC1401, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Maillart+E%22">Maillart E</searchLink>; Département de Neurologie, Hôpital Pitié-Salpêtrière, APHP, Centre de Ressources et de Compétences SEP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Labauge+P%22">Labauge P</searchLink>; MS Unit, CHU de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Zephir+H%22">Zephir H</searchLink>; CRC-SEP Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Papeix+C%22">Papeix C</searchLink>; Department of Neurology, Fondation Rothschild, Paris, France.<br /><searchLink fieldCode="AU" term="%22Defer+G%22">Defer G</searchLink>; Department of Neurology, MS Expert Centre, CHU de Caen, Caen, France.<br /><searchLink fieldCode="AU" term="%22Lebrun-Frenay+C%22">Lebrun-Frenay C</searchLink>; Neurology, UR2CA-URRIS, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Moreau+T%22">Moreau T</searchLink>; Department of Neurology, CHU de Dijon, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Laplaud+DA%22">Laplaud DA</searchLink>; Department of Neurology, CHU de Nantes, Nantes, France.; Nantes Université, CHU Nantes, INSERM, CIC 14131413, Center for Research in Translational Immunology, UMR 1064, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Berger+E%22">Berger E</searchLink>; Service de Neurologie, CHU de Besançon, Besançon, France.<br /><searchLink fieldCode="AU" term="%22Stankoff+B%22">Stankoff B</searchLink>; Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Clavelou+P%22">Clavelou P</searchLink>; Department of Neurology, CHU Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Thouvenot+E%22">Thouvenot E</searchLink>; Department of Neurology, Nimes University Hospital, Nimes, France.<br /><searchLink fieldCode="AU" term="%22Heinzlef+O%22">Heinzlef O</searchLink>; Hôpital de Poissy, Department of Neurology, Poissy, France.<br /><searchLink fieldCode="AU" term="%22Pelletier+J%22">Pelletier J</searchLink>; Service de Neurologie, APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Al-Khedr+A%22">Al-Khedr A</searchLink>; CHU d'Amiens, Department of Neurology, Amiens, France.<br /><searchLink fieldCode="AU" term="%22Casez+O%22">Casez O</searchLink>; CHU Grenoble Alpes, Department of Neurology, Neurology MS Clinic Grenoble, Grenoble Alpes University Hospital, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Bourre+B%22">Bourre B</searchLink>; CHU de Rouen, Department of Neurology, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Cabre+P%22">Cabre P</searchLink>; Department of Neurology, CHU de la Martinique, Fort-de-France, France.<br /><searchLink fieldCode="AU" term="%22Wahab+A%22">Wahab A</searchLink>; Department of Neurology, APHP, Hôpital Henri Mondor, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Magy+L%22">Magy L</searchLink>; Department of Neurology, CHU de Limoges, Hôpital Dupuytren, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Camdessanché+JP%22">Camdessanché JP</searchLink>; Department of Neurology, CHU de Saint-Étienne, Hôpital Nord, Saint-Étienne, France.<br /><searchLink fieldCode="AU" term="%22Doghri+I%22">Doghri I</searchLink>; Department of Neurology, CHU de Tours, Hôpital Bretonneau, Tours, France.<br /><searchLink fieldCode="AU" term="%22Moulin+S%22">Moulin S</searchLink>; Department of Neurology, CHU de Reims, CRC-SEP, Reims, France.<br /><searchLink fieldCode="AU" term="%22Ben-Nasr+H%22">Ben-Nasr H</searchLink>; Hôpital Sud Francilien, Department of Neurology, Corbeil-Essonnes, France.<br /><searchLink fieldCode="AU" term="%22Labeyrie+C%22">Labeyrie C</searchLink>; Department of Neurology, CHU Bicêtre, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Hankiewicz+K%22">Hankiewicz K</searchLink>; Department of Neurology, Hôpital Pierre Delafontaine, Centre Hospitalier de Saint-Denis, Saint-Denis, France.<br /><searchLink fieldCode="AU" term="%22Neau+JP%22">Neau JP</searchLink>; Department of Neurology, CHU La Milétrie, Hôpital Jean Bernard, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Pottier+C%22">Pottier C</searchLink>; Department of Neurology, CH de Pontoise, Hôpital René Dubos, Pontoise, France.<br /><searchLink fieldCode="AU" term="%22Nifle+C%22">Nifle C</searchLink>; Departement of Neurology, Centre Hospitalier de Versailles, Le Chesnay, France.<br /><searchLink fieldCode="AU" term="%22Collongues+N%22">Collongues N</searchLink>; Center for Clinical Investigation, INSERM U1434, Strasbourg, France.; Biopathology of Myelin, Neuroprotection and Therapeutic Strategy, INSERM U1119, Strasbourg, France.; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.; Department of Pharmacology, Addictology, Toxicology and Therapeutics, Strasbourg University, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Kerbrat+A%22">Kerbrat A</searchLink>; Department of Neurology, University Hospital of Rennes, Rennes, France.; CIC-P 1414 INSERM, University Hospital of Rennes, Rennes, France.; Empenn U1228, University of Rennes, Inria, CNRS, INSERM, IRISA UMR 6074, Rennes, France.
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      – PersonEntity:
          Name:
            NameFull: Collongues N
      – PersonEntity:
          Name:
            NameFull: Kerbrat A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2024 May 01
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 2168-6157
          Numbering:
            – Type: volume
              Value: 81
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: JAMA neurology
              Type: main
ResultId 1