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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.

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Title: Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
Authors: Liu J; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Vernikovskaya D; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Bora G; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Carlo A; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Burchett W; Global Biometrics and Data Management, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Jordan S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Tang LWT; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Yang J; Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA., Che Y; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Chang G; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Troutman MD; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA., Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA. li.di@recursionpharma.com.; Recursion Pharmaceuticals, Salt Lake City, UT, USA. li.di@recursionpharma.com.
Source: The AAPS journal [AAPS J] 2024 Mar 28; Vol. 26 (3), pp. 36. Date of Electronic Publication: 2024 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Vernikovskaya+D%22">Vernikovskaya D</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Bora+G%22">Bora G</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Carlo+A%22">Carlo A</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Burchett+W%22">Burchett W</searchLink>; Global Biometrics and Data Management, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Jordan+S%22">Jordan S</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Tang+LWT%22">Tang LWT</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Che+Y%22">Che Y</searchLink>; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Chang+G%22">Chang G</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Troutman+MD%22">Troutman MD</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Di+L%22">Di L</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA. li.di@recursionpharma.com.; Recursion Pharmaceuticals, Salt Lake City, UT, USA. li.di@recursionpharma.com.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2024 Mar 28; Vol. 26 (3), pp. 36. <i>Date of Electronic Publication: </i>2024 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE
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