Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial.
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| Title: | Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial. |
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| Authors: | Gladwin MT; University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mgladwin@som.umaryland.edu., Gordeuk VR; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Desai PC; Levine Cancer Institute, Atrium Health, Wake Forest School of Medicine, Charlotte, NC, USA., Minniti C; Albert Einstein College of Medicine, New York, NY, USA., Novelli EM; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA., Morris CR; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatric Emergency Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA., Ataga KI; Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., De Castro L; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA., Curtis SA; Icahn School of Medicine at Mount Sinai, New York, NY, USA., El Rassi F; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA; Georgia Comprehensive Sickle Cell Clinic at Grady Health System, Atlanta, GA, USA., Ford HJ; Pulmonary Hypertension Program, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Harrington T; Division of Hematology, Department of Medicine, University of Miami, Miami, FL, USA., Klings ES; The Pulmonary Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Lanzkron S; Sickle Cell Center for Adults, Johns Hopkins School of Medicine, Baltimore, MD, USA., Liles D; Brody School of Medicine East Carolina University, Greenville, NC, USA., Little J; University of North Carolina Comprehensive Sickle Cell Disease Program and Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nero A; University of Texas Southwestern Medical Center, Dallas, TX, USA., Smith W; Division of General Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA., Taylor JG 6th; Center for Sickle Cell Disease, Departments of Medicine (Hematology and Oncology) and Microbiology and Immunology, Howard University College of Medicine, Washington, DC, USA; Department of Food and Human Nutrition Sciences, University of Manitoba, Winnipeg, MB, Canada., Baptiste A; Department of Medicine, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA., Hagar W; Internal Medicine, Department of Pediatrics, University of California San Francisco, Benioff Children's Hospital Oakland, Oakland, CA, USA., Kanter J; Hematology Oncology, Department of Internal Medicine, University of Alabama Birmingham, Birmingham, AL, USA., Kinzie A; Sickle Cell Center of Southern Louisiana, Tulane University School of Medicine, New Orleans, LA, USA., Martin T; Medical University of South Carolina, Charleston, SC, USA., Rafique A; Sickle Cell Center of Southern Louisiana, Tulane University School of Medicine, New Orleans, LA, USA., Telen MJ; Division of Hematology, Department of Medicine, Duke University School of Medicine, and Duke Comprehensive Sickle Cell Center, Durham, NC, USA., Lalama CM; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Clinical Trials & Data Coordination, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kato GJ; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA., Abebe KZ; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Clinical Trials & Data Coordination, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. |
| Source: | The Lancet. Haematology [Lancet Haematol] 2024 May; Vol. 11 (5), pp. e345-e357. Date of Electronic Publication: 2024 Mar 27. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Clinical Trial, Phase I |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38554715 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gladwin+MT%22">Gladwin MT</searchLink>; University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mgladwin@som.umaryland.edu.<br /><searchLink fieldCode="AU" term="%22Gordeuk+VR%22">Gordeuk VR</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Desai+PC%22">Desai PC</searchLink>; Levine Cancer Institute, Atrium Health, Wake Forest School of Medicine, Charlotte, NC, USA.<br /><searchLink fieldCode="AU" term="%22Minniti+C%22">Minniti C</searchLink>; Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Novelli+EM%22">Novelli EM</searchLink>; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+CR%22">Morris CR</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatric Emergency Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ataga+KI%22">Ataga KI</searchLink>; Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22De+Castro+L%22">De Castro L</searchLink>; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+SA%22">Curtis SA</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22El+Rassi+F%22">El Rassi F</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA; Georgia Comprehensive Sickle Cell Clinic at Grady Health System, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ford+HJ%22">Ford HJ</searchLink>; Pulmonary Hypertension Program, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Harrington+T%22">Harrington T</searchLink>; Division of Hematology, Department of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Klings+ES%22">Klings ES</searchLink>; The Pulmonary Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lanzkron+S%22">Lanzkron S</searchLink>; Sickle Cell Center for Adults, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liles+D%22">Liles D</searchLink>; Brody School of Medicine East Carolina University, Greenville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Little+J%22">Little J</searchLink>; University of North Carolina Comprehensive Sickle Cell Disease Program and Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nero+A%22">Nero A</searchLink>; University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Smith+W%22">Smith W</searchLink>; Division of General Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+JG+6th%22">Taylor JG 6th</searchLink>; Center for Sickle Cell Disease, Departments of Medicine (Hematology and Oncology) and Microbiology and Immunology, Howard University College of Medicine, Washington, DC, USA; Department of Food and Human Nutrition Sciences, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Baptiste+A%22">Baptiste A</searchLink>; Department of Medicine, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hagar+W%22">Hagar W</searchLink>; Internal Medicine, Department of Pediatrics, University of California San Francisco, Benioff Children's Hospital Oakland, Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kanter+J%22">Kanter J</searchLink>; Hematology Oncology, Department of Internal Medicine, University of Alabama Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kinzie+A%22">Kinzie A</searchLink>; Sickle Cell Center of Southern Louisiana, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+T%22">Martin T</searchLink>; Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Rafique+A%22">Rafique A</searchLink>; Sickle Cell Center of Southern Louisiana, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Telen+MJ%22">Telen MJ</searchLink>; Division of Hematology, Department of Medicine, Duke University School of Medicine, and Duke Comprehensive Sickle Cell Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lalama+CM%22">Lalama CM</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Clinical Trials & Data Coordination, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kato+GJ%22">Kato GJ</searchLink>; Department of Medicine, Division of Hematology and Oncology, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Abebe+KZ%22">Abebe KZ</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Clinical Trials & Data Coordination, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2024 May; Vol. 11 (5), pp. e345-e357. <i>Date of Electronic Publication: </i>2024 Mar 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101643584 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3026 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523026%22">23523026 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Haematol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38554715 |
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