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Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.

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Title: Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Authors: Zhou Y; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Ray PS; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Zhu J; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Stein F; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Rettel M; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Sekaran T; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Sahadevan S; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Perez-Perri JI; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Roth EK; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Myklebost O; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Meza-Zepeda LA; Genomics Core Facility, Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., von Deimling A; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany., Fu C; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Brosig AN; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Boye K; Department of Oncology, Oslo University Hospital, Oslo, Norway., Nathrath M; Department of Pediatrics and Children's Cancer Research Center, Technical University of Munich, School of Medicine, Munich, Germany.; Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Olga Hospital, Stuttgart, Germany., Blattmann C; Department of Pediatric Oncology, Hematology and Immunology, Olga Hospital, Stuttgart, Germany., Lehner B; Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany., Hentze MW; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. hentze@embl.org.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. hentze@embl.org., Kulozik AE; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.
Source: Nature communications [Nat Commun] 2024 Apr 01; Vol. 15 (1), pp. 2810. Date of Electronic Publication: 2024 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ray+PS%22">Ray PS</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stein+F%22">Stein F</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rettel+M%22">Rettel M</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sekaran+T%22">Sekaran T</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sahadevan+S%22">Sahadevan S</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Perez-Perri+JI%22">Perez-Perri JI</searchLink>; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Roth+EK%22">Roth EK</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Myklebost+O%22">Myklebost O</searchLink>; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Meza-Zepeda+LA%22">Meza-Zepeda LA</searchLink>; Genomics Core Facility, Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22von+Deimling+A%22">von Deimling A</searchLink>; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fu+C%22">Fu C</searchLink>; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brosig+AN%22">Brosig AN</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Boye+K%22">Boye K</searchLink>; Department of Oncology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nathrath+M%22">Nathrath M</searchLink>; Department of Pediatrics and Children's Cancer Research Center, Technical University of Munich, School of Medicine, Munich, Germany.; Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Olga Hospital, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Blattmann+C%22">Blattmann C</searchLink>; Department of Pediatric Oncology, Hematology and Immunology, Olga Hospital, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Lehner+B%22">Lehner B</searchLink>; Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hentze+MW%22">Hentze MW</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. hentze@embl.org.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. hentze@embl.org.<br /><searchLink fieldCode="AU" term="%22Kulozik+AE%22">Kulozik AE</searchLink>; Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.
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