Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.

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Title: Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
Authors: Mittal K; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Cooper GW; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Lee BP; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Su Y; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Skinner KT; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Shim J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Jonus HC; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Kim WJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Doshi M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Almanza D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kynnap BD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Christie AL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Yang X; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cowley GS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Leeper BA; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Morton CL; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Dwivedi B; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Lawrence T; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Rupji M; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Keskula P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Meyer S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Clinton CM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bhasin M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Crompton BD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tseng YY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Murphy AJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Merck & Co., Rahway, NJ, USA., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Spangle JM; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA., Rivera MN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Mullen EA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Stegmaier K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Goldsmith KC; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_hahn@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_hahn@dfci.harvard.edu., Hong AL; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. andrew.hong2@emory.edu.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. andrew.hong2@emory.edu.; Winship Cancer Institute, Emory University, Atlanta, GA, USA. andrew.hong2@emory.edu.
Source: Communications biology [Commun Biol] 2024 Apr 08; Vol. 7 (1), pp. 426. Date of Electronic Publication: 2024 Apr 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
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  Data: <searchLink fieldCode="AU" term="%22Mittal+K%22">Mittal K</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cooper+GW%22">Cooper GW</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+BP%22">Lee BP</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Skinner+KT%22">Skinner KT</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Shim+J%22">Shim J</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jonus+HC%22">Jonus HC</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+WJ%22">Kim WJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doshi+M%22">Doshi M</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Almanza+D%22">Almanza D</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kynnap+BD%22">Kynnap BD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Christie+AL%22">Christie AL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cowley+GS%22">Cowley GS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Leeper+BA%22">Leeper BA</searchLink>; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morton+CL%22">Morton CL</searchLink>; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Dwivedi+B%22">Dwivedi B</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+T%22">Lawrence T</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rupji+M%22">Rupji M</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Keskula+P%22">Keskula P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+S%22">Meyer S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Clinton+CM%22">Clinton CM</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bhasin+M%22">Bhasin M</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Crompton+BD%22">Crompton BD</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+YY%22">Tseng YY</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boehm+JS%22">Boehm JS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ligon+KL%22">Ligon KL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Root+DE%22">Root DE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+AJ%22">Murphy AJ</searchLink>; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Weinstock+DM%22">Weinstock DM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Merck & Co., Rahway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Gokhale+PC%22">Gokhale PC</searchLink>; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spangle+JM%22">Spangle JM</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+MN%22">Rivera MN</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mullen+EA%22">Mullen EA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stegmaier+K%22">Stegmaier K</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goldsmith+KC%22">Goldsmith KC</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hahn+WC%22">Hahn WC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_hahn@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_hahn@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Hong+AL%22">Hong AL</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. andrew.hong2@emory.edu.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. andrew.hong2@emory.edu.; Winship Cancer Institute, Emory University, Atlanta, GA, USA. andrew.hong2@emory.edu.
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