A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death.

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Title: A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death.
Authors: Ray A; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. arghya_ray@dfci.harvard.edu., Du T; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Wan X; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Song Y; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Pillai SC; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Musa MA; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Fang T; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Moore J; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Blank B; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Du X; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Chen X; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Warne R; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Sutimantanapi D; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Lui F; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Zavorotinskaya T; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Colas C; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Friedman L; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Junttila MR; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA., Chauhan D; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Dharminder_Chauhan@dfci.harvard.edu., Anderson KC; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Kenneth_Anderson@dfci.harvard.edu.
Source: Blood cancer journal [Blood Cancer J] 2024 Apr 09; Vol. 14 (1), pp. 58. Date of Electronic Publication: 2024 Apr 09.
Publication Type: Letter; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death.
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  Data: <searchLink fieldCode="AU" term="%22Ray+A%22">Ray A</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. arghya_ray@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Du+T%22">Du T</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wan+X%22">Wan X</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pillai+SC%22">Pillai SC</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Musa+MA%22">Musa MA</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fang+T%22">Fang T</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+J%22">Moore J</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blank+B%22">Blank B</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Warne+R%22">Warne R</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sutimantanapi+D%22">Sutimantanapi D</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lui+F%22">Lui F</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zavorotinskaya+T%22">Zavorotinskaya T</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Colas+C%22">Colas C</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Friedman+L%22">Friedman L</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Junttila+MR%22">Junttila MR</searchLink>; ORIC Pharmaceuticals, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chauhan+D%22">Chauhan D</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Dharminder_Chauhan@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Anderson+KC%22">Anderson KC</searchLink>; The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Kenneth_Anderson@dfci.harvard.edu.
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