Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme.

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Title: Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme.
Authors: Oporto Espuelas M; Infection, Immunity and Inflammation, UCL Great Ormond Ormond Street Institute of Child Health, London, UK. m.oporto@ucl.ac.uk., Burridge S; Department of Haematology, Great Ormond Street Hospital, London, UK., Kirkwood AA; Cancer Research UK & Cancer Trials Centre, UCL, London, UK., Bonney D; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK., Watts K; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK., Shenton G; Great North Children's Hospital, Newcastle upon Tyne, UK., Jalowiec KA; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., O'Reilly MA; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Roddie C; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Castleton A; Department of Haematology, The Christie Hospital NHS Foundation Trust, Manchester, UK., Clesham K; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Nicholson E; Department of Haematology/Bone Marrow Transplantation, The Royal Marsden NHS Foundation Trust, London, UK.; Institute of Cancer Research, London, UK., Alajangi R; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Prabhu S; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., George L; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Uttenthal B; Cambridge University Hospital NHS Foundation Trust, Cambridge, UK., Gabelli M; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.; Pediatric Onco-hematology and Hematopoietic Stem Cell Transplantation, Woman and Child Health Department, University of Padova, Padua, Italy., Neill L; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Besley C; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Chaganti S; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK., Wynn RF; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK., Bartram J; Department of Haematology, Great Ormond Street Hospital, London, UK., Chiesa R; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK., Lucchini G; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK., Pavasovic V; Department of Haematology, Great Ormond Street Hospital, London, UK., Rao A; Department of Haematology, Great Ormond Street Hospital, London, UK., Rao K; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK., Silva J; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK., Samarasinghe S; Department of Haematology, Great Ormond Street Hospital, London, UK., Vora A; Department of Haematology, Great Ormond Street Hospital, London, UK., Clark P; NHS England, London, UK., Cummins M; Bristol Royal Hospital for Children, Bristol, UK., Marks DI; Department of Haematology, University Hospitals Bristol, Bristol, UK., Amrolia P; Infection, Immunity and Inflammation, UCL Great Ormond Ormond Street Institute of Child Health, London, UK.; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK., Hough R; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Ghorashian S; Department of Haematology, Great Ormond Street Hospital, London, UK.; Developmental Biology and Cancer, UCL Great Ormond Ormond Street Institute of Child Health, London, UK.
Source: Blood cancer journal [Blood Cancer J] 2024 Apr 15; Vol. 14 (1), pp. 66. Date of Electronic Publication: 2024 Apr 15.
Publication Type: Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme.
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  Data: <searchLink fieldCode="AU" term="%22Oporto+Espuelas+M%22">Oporto Espuelas M</searchLink>; Infection, Immunity and Inflammation, UCL Great Ormond Ormond Street Institute of Child Health, London, UK. m.oporto@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Burridge+S%22">Burridge S</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Kirkwood+AA%22">Kirkwood AA</searchLink>; Cancer Research UK & Cancer Trials Centre, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Bonney+D%22">Bonney D</searchLink>; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Watts+K%22">Watts K</searchLink>; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Shenton+G%22">Shenton G</searchLink>; Great North Children's Hospital, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Jalowiec+KA%22">Jalowiec KA</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Reilly+MA%22">O'Reilly MA</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Roddie+C%22">Roddie C</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Castleton+A%22">Castleton A</searchLink>; Department of Haematology, The Christie Hospital NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Clesham+K%22">Clesham K</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Nicholson+E%22">Nicholson E</searchLink>; Department of Haematology/Bone Marrow Transplantation, The Royal Marsden NHS Foundation Trust, London, UK.; Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Alajangi+R%22">Alajangi R</searchLink>; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Prabhu+S%22">Prabhu S</searchLink>; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22George+L%22">George L</searchLink>; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Uttenthal+B%22">Uttenthal B</searchLink>; Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gabelli+M%22">Gabelli M</searchLink>; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.; Pediatric Onco-hematology and Hematopoietic Stem Cell Transplantation, Woman and Child Health Department, University of Padova, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Neill+L%22">Neill L</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Besley+C%22">Besley C</searchLink>; Department of Haematology/Bone Marrow Transplant, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Chaganti+S%22">Chaganti S</searchLink>; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Wynn+RF%22">Wynn RF</searchLink>; Department of Blood and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Bartram+J%22">Bartram J</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Chiesa+R%22">Chiesa R</searchLink>; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Lucchini+G%22">Lucchini G</searchLink>; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Pavasovic+V%22">Pavasovic V</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Rao+A%22">Rao A</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Rao+K%22">Rao K</searchLink>; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Silva+J%22">Silva J</searchLink>; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Samarasinghe+S%22">Samarasinghe S</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Vora+A%22">Vora A</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Clark+P%22">Clark P</searchLink>; NHS England, London, UK.<br /><searchLink fieldCode="AU" term="%22Cummins+M%22">Cummins M</searchLink>; Bristol Royal Hospital for Children, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Marks+DI%22">Marks DI</searchLink>; Department of Haematology, University Hospitals Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Amrolia+P%22">Amrolia P</searchLink>; Infection, Immunity and Inflammation, UCL Great Ormond Ormond Street Institute of Child Health, London, UK.; Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Hough+R%22">Hough R</searchLink>; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ghorashian+S%22">Ghorashian S</searchLink>; Department of Haematology, Great Ormond Street Hospital, London, UK.; Developmental Biology and Cancer, UCL Great Ormond Ormond Street Institute of Child Health, London, UK.
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  Data: <searchLink fieldCode="JN" term="%22101568469%22">Blood cancer journal</searchLink> [Blood Cancer J] 2024 Apr 15; Vol. 14 (1), pp. 66. <i>Date of Electronic Publication: </i>2024 Apr 15.
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