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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.

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Title: Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
Authors: Kim SH; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Han S; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Zhao J; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Wang S; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Kusnetzow AK; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Reinhart G; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Fowler MA; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Markison S; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Johns M; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Luo R; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Struthers RS; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Zhu Y; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States., Betz SF; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Mar 19; Vol. 15 (4), pp. 478-485. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
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  Data: <searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kusnetzow+AK%22">Kusnetzow AK</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Reinhart+G%22">Reinhart G</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Fowler+MA%22">Fowler MA</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Markison+S%22">Markison S</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Johns+M%22">Johns M</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Luo+R%22">Luo R</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Struthers+RS%22">Struthers RS</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Betz+SF%22">Betz SF</searchLink>; Crinetics Pharmaceuticals, Inc., 6055 Lusk Blvd., San Diego, California 92121, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2024 Mar 19; Vol. 15 (4), pp. 478-485. <i>Date of Electronic Publication: </i>2024 Mar 19 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2024 Mar 19
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