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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

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Title: Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.
Authors: Pottenger AE; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Roy D; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Srinivasan S; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Chavas TEJ; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Vlaskin V; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Ho DK; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Livingston VC; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Maktabi M; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA., Lin H; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Zhang J; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Pybus B; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Kudyba K; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Roth A; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Senter P; Seagen, Bothell, WA 98021, USA., Tyson G; George Tyson Consulting, Los Altos Hills, CA 94022, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA., Huber HE; BioTD Strategies LLC, 213 Abbey Ln., Lansdale, PA 19446, USA., Wesche D; Certara, Princeton, NJ 08540, USA., Rochford R; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA., Burke PA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Burke Bioventures LLC, 1 Broadway 14th Floor, Cambridge, MA 02142, USA., Stayton PS; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Source: Science advances [Sci Adv] 2024 Apr 19; Vol. 10 (16), pp. eadk4492. Date of Electronic Publication: 2024 Apr 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.
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  Data: <searchLink fieldCode="AU" term="%22Pottenger+AE%22">Pottenger AE</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Roy+D%22">Roy D</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Srinivasan+S%22">Srinivasan S</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Chavas+TEJ%22">Chavas TEJ</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Vlaskin+V%22">Vlaskin V</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Ho+DK%22">Ho DK</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Livingston+VC%22">Livingston VC</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Maktabi+M%22">Maktabi M</searchLink>; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.<br /><searchLink fieldCode="AU" term="%22Pybus+B%22">Pybus B</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.<br /><searchLink fieldCode="AU" term="%22Kudyba+K%22">Kudyba K</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.<br /><searchLink fieldCode="AU" term="%22Roth+A%22">Roth A</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.<br /><searchLink fieldCode="AU" term="%22Senter+P%22">Senter P</searchLink>; Seagen, Bothell, WA 98021, USA.<br /><searchLink fieldCode="AU" term="%22Tyson+G%22">Tyson G</searchLink>; George Tyson Consulting, Los Altos Hills, CA 94022, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Huber+HE%22">Huber HE</searchLink>; BioTD Strategies LLC, 213 Abbey Ln., Lansdale, PA 19446, USA.<br /><searchLink fieldCode="AU" term="%22Wesche+D%22">Wesche D</searchLink>; Certara, Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Rochford+R%22">Rochford R</searchLink>; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Burke+PA%22">Burke PA</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.; Burke Bioventures LLC, 1 Broadway 14th Floor, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Stayton+PS%22">Stayton PS</searchLink>; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2024 Apr 19; Vol. 10 (16), pp. eadk4492. <i>Date of Electronic Publication: </i>2024 Apr 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101653440 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2375-2548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223752548%22">23752548 </searchLink><i>NLM ISO Abbreviation: </i>Sci Adv <i>Subsets: </i>MEDLINE
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