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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation.

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Title: Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation.
Authors: McNutt SW; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.; co-first author, equally contributed to the work., Roychowdhury T; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; co-first author, equally contributed to the work., Pasala C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Nguyen HT; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA., Thornton DT; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA., Sharma S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Botticelli L; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA., Digwal CS; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Joshi S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yang N; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA., Panchal P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chakrabarty S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bay S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Markov V; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kwong C; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lisanti J; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chung SY; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ginsberg SD; Departments of Psychiatry, Neuroscience & Physiology & the NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA., Yan P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., DeStanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Corben A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Modi S; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Alpaugh M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Colombo G; Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy., Erdjument-Bromage H; Department of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA., Neubert TA; Department of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA., Chalkley RJ; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA., Baker PR; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA., Burlingame AL; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA., Rodina A; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; These authors jointly supervised this work: Feixia Chu, Gabriela Chiosis., Chu F; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, USA.; These authors jointly supervised this work: Feixia Chu, Gabriela Chiosis.
Source: Research square [Res Sq] 2024 Apr 03. Date of Electronic Publication: 2024 Apr 03.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22McNutt+SW%22">McNutt SW</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.; co-first author, equally contributed to the work.<br /><searchLink fieldCode="AU" term="%22Roychowdhury+T%22">Roychowdhury T</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; co-first author, equally contributed to the work.<br /><searchLink fieldCode="AU" term="%22Pasala+C%22">Pasala C</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+HT%22">Nguyen HT</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.<br /><searchLink fieldCode="AU" term="%22Thornton+DT%22">Thornton DT</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Botticelli+L%22">Botticelli L</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.<br /><searchLink fieldCode="AU" term="%22Digwal+CS%22">Digwal CS</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+S%22">Joshi S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yang+N%22">Yang N</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.<br /><searchLink fieldCode="AU" term="%22Panchal+P%22">Panchal P</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+S%22">Chakrabarty S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bay+S%22">Bay S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Markov+V%22">Markov V</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+C%22">Kwong C</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Lisanti+J%22">Lisanti J</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chung+SY%22">Chung SY</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ginsberg+SD%22">Ginsberg SD</searchLink>; Departments of Psychiatry, Neuroscience & Physiology & the NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.<br /><searchLink fieldCode="AU" term="%22Yan+P%22">Yan P</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22DeStanchina+E%22">DeStanchina E</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Corben+A%22">Corben A</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Modi+S%22">Modi S</searchLink>; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Alpaugh+M%22">Alpaugh M</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Colombo+G%22">Colombo G</searchLink>; Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Erdjument-Bromage+H%22">Erdjument-Bromage H</searchLink>; Department of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.<br /><searchLink fieldCode="AU" term="%22Neubert+TA%22">Neubert TA</searchLink>; Department of Neuroscience and Physiology and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016, USA.<br /><searchLink fieldCode="AU" term="%22Chalkley+RJ%22">Chalkley RJ</searchLink>; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA.<br /><searchLink fieldCode="AU" term="%22Baker+PR%22">Baker PR</searchLink>; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA.<br /><searchLink fieldCode="AU" term="%22Burlingame+AL%22">Burlingame AL</searchLink>; Mass Spectrometry Facility, University of California, San Francisco, California 94143, USA.<br /><searchLink fieldCode="AU" term="%22Rodina+A%22">Rodina A</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chiosis+G%22">Chiosis G</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; These authors jointly supervised this work: Feixia Chu, Gabriela Chiosis.<br /><searchLink fieldCode="AU" term="%22Chu+F%22">Chu F</searchLink>; Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.; Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, USA.; These authors jointly supervised this work: Feixia Chu, Gabriela Chiosis.
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