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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

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Title: Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Authors: Ferretti S; Novartis BioMedical Research, Basel, Switzerland., Hamon J; Novartis BioMedical Research, Basel, Switzerland., de Kanter R; Novartis BioMedical Research, Basel, Switzerland., Scheufler C; Novartis BioMedical Research, Basel, Switzerland., Andraos-Rey R; Novartis BioMedical Research, Basel, Switzerland., Barbe S; Novartis BioMedical Research, Basel, Switzerland., Bechter E; Novartis BioMedical Research, Basel, Switzerland., Blank J; Novartis BioMedical Research, Basel, Switzerland., Bordas V; Novartis BioMedical Research, Basel, Switzerland., Dammassa E; Novartis BioMedical Research, Basel, Switzerland., Decker A; Novartis BioMedical Research, Basel, Switzerland., Di Nanni N; Novartis BioMedical Research, Basel, Switzerland., Dourdoigne M; Novartis BioMedical Research, Basel, Switzerland., Gavioli E; Novartis BioMedical Research, Basel, Switzerland.; Novartis Pharma AG, Basel, Switzerland., Hattenberger M; Novartis BioMedical Research, Basel, Switzerland., Heuser A; Novartis BioMedical Research, Basel, Switzerland., Hemmerlin C; Novartis BioMedical Research, Basel, Switzerland., Hinrichs J; Novartis BioMedical Research, Basel, Switzerland., Kerr G; Novartis BioMedical Research, Basel, Switzerland., Laborde L; Novartis BioMedical Research, Basel, Switzerland., Jaco I; Novartis BioMedical Research, Basel, Switzerland., Núñez EJ; Novartis BioMedical Research, Basel, Switzerland.; Pierre Fabre Laboratories, Toulouse, France., Martus HJ; Novartis BioMedical Research, Basel, Switzerland., Quadt C; Novartis BioMedical Research, Basel, Switzerland., Reschke M; Novartis BioMedical Research, Basel, Switzerland., Romanet V; Novartis BioMedical Research, Basel, Switzerland., Schaeffer F; Novartis BioMedical Research, Basel, Switzerland., Schoepfer J; Novartis BioMedical Research, Basel, Switzerland., Schrapp M; Novartis BioMedical Research, Basel, Switzerland., Strang R; Novartis BioMedical Research, Basel, Switzerland., Voshol H; Novartis BioMedical Research, Basel, Switzerland., Wartmann M; Novartis BioMedical Research, Basel, Switzerland., Welly S; Novartis BioMedical Research, Basel, Switzerland., Zécri F; Novartis BioMedical Research, Cambridge, MA, USA., Hofmann F; Novartis BioMedical Research, Basel, Switzerland.; Pierre Fabre Laboratories, Toulouse, France., Möbitz H; Novartis BioMedical Research, Basel, Switzerland. henrik.moebitz@novartis.com., Cortés-Cros M; Novartis BioMedical Research, Basel, Switzerland. marta.cortes-cros@novartis.com.
Source: Nature [Nature] 2024 May; Vol. 629 (8011), pp. 443-449. Date of Electronic Publication: 2024 Apr 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2024 May; Vol. 629 (8011), pp. 443-449. <i>Date of Electronic Publication: </i>2024 Apr 24.
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