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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

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Title: Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
Authors: Keaton JM; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. a.vaez@umcg.nl.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. a.vaez@umcg.nl., Williams A; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Goleva SB; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.; Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Ioannina, Greece., Hellwege JN; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Young WJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Traylor M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Giri A; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Zheng Z; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zeng J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Chasman DI; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hwang SJ; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University, Boston, MA, USA., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Attia JR; Faculty of Health and Medicine, University of Newcastle, New Lambton Heights, Newcastle, New South Wales, Australia., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kristiansson K; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Schmidt R; Department of Neurology/Medical University Graz, Graz, Austria., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Risch L; Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Department of Laboratory Medicine, Dr. Risch Anstalt, Vaduz, Liechtenstein., Gyllensten U; Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Melander O; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden., Riese H; Interdisciplinary Center Psychopathology and Emotional Regulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Lu Y; Vanderbilt Genetic Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Sundström J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Kutalik Z; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Trompet S; Department Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., van der Harst P; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ridker PM; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Giulianini F; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harris SE; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Manchester Heart Institute, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Campbell A; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Scott LJ; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boutin T; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Mamasoula C; Population Health Sciences Institute, Newcastle University, Newcastle, UK., Järvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Lehrstuhl für Epidemiologie, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Cucca F; Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Italy., Hui J; Busselton Population Medical Research Institute, Perth, Western Australia, Australia.; School of Population and Global Health, The University of Western Australia, Nedlands, Western Australia, Australia., Knekt P; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Enroth S; Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Uppsala, Sweden., De Borst MH; Department of Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Polašek O; University of Split School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Catamo E; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Cocca M; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Spedicati B; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Waldenberger M; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Strachan DP; Population Health Sciences Institute St George's, University of London, London, UK., Laan M; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Dörr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Kopavogur, Iceland., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Ruggiero D; IRCCS Neuromed, Pozzilli, Italy.; Institute of Genetics and Biophysics - 'A. Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Kolcic I; Algebra University College, Zagreb, Croatia.; Department of Public Health, University of Split School of Medicine, Split, Croatia., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Johnson AD; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Newton-Cheh C; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Sever PJ; International Centre for Circulatory Health, Imperial College London, London, UK., Poulter N; School of Public Health, Imperial College London, London, UK., Chambers JC; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Elosua R; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.; CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain.; Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Siscovick D; New York Academy of Medicine, New York, NY, USA., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Institute of Genomics, University of Tartu, Tartu, Estonia., Strawbridge RJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Health Data Research UK, Glasgow, UK.; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Hamsten A; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Hottenga JJ; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands., de Geus E; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, Amsterdam, the Netherlands., Morris AD; Data Science, University of Edinburgh, Edinburgh, UK.; Health Data Research UK, London, UK., Palmer CNA; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Milaneschi Y; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Marten J; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Wright A; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Howson JMM; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., O'Donnell CJ; VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Spector T; Department of Twin Research, King's College London, London, UK., Nalls MA; Center for Alzheimer's and Related Dementias, NIA/NINDS, NIH, Bethesda, MD, USA.; Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Simonsick EM; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Liu Y; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., van Duijn CM; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK., Danesh JN; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Human Genetics, The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Menni C; Department of Twin Research and Genetic Epidemiology, London, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, UK., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.; VA Atlanta Healthcare System, Decatur, GA, USA., Wilson PWF; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Cho K; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Denny JC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Levy D; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. todd.l.edwards@vumc.org., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.
Corporate Authors: Million Veteran Program, Lifelines Cohort Study, CHARGE consortium, ICBP Consortium
Source: Nature genetics [Nat Genet] 2024 May; Vol. 56 (5), pp. 778-791. Date of Electronic Publication: 2024 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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Items – Name: Title
  Label: Title
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  Data: Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Keaton+JM%22">Keaton JM</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kamali+Z%22">Kamali Z</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.<br /><searchLink fieldCode="AU" term="%22Xie+T%22">Xie T</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vaez+A%22">Vaez A</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. a.vaez@umcg.nl.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. a.vaez@umcg.nl.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Goleva+SB%22">Goleva SB</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ani+A%22">Ani A</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.<br /><searchLink fieldCode="AU" term="%22Evangelou+E%22">Evangelou E</searchLink>; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.; Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Hellwege+JN%22">Hellwege JN</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yengo+L%22">Yengo L</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Young+WJ%22">Young WJ</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Traylor+M%22">Traylor M</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Giri+A%22">Giri A</searchLink>; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+Z%22">Zheng Z</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Chasman+DI%22">Chasman DI</searchLink>; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Caulfield+MJ%22">Caulfield MJ</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hwang+SJ%22">Hwang SJ</searchLink>; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kooner+JS%22">Kooner JS</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Conen+D%22">Conen D</searchLink>; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Attia+JR%22">Attia JR</searchLink>; Faculty of Health and Medicine, University of Newcastle, New Lambton Heights, Newcastle, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Morrison+AC%22">Morrison AC</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kristiansson+K%22">Kristiansson K</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Schmidt+R%22">Schmidt R</searchLink>; Department of Neurology/Medical University Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Hicks+AA%22">Hicks AA</searchLink>; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Pramstaller+PP%22">Pramstaller PP</searchLink>; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Risch+L%22">Risch L</searchLink>; Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Department of Laboratory Medicine, Dr. Risch Anstalt, Vaduz, Liechtenstein.<br /><searchLink fieldCode="AU" term="%22Gyllensten+U%22">Gyllensten U</searchLink>; Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Melander+O%22">Melander O</searchLink>; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Riese+H%22">Riese H</searchLink>; Interdisciplinary Center Psychopathology and Emotional Regulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wilson+JF%22">Wilson JF</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Campbell+H%22">Campbell H</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Vanderbilt Genetic Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rice+KM%22">Rice KM</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Vollenweider+P%22">Vollenweider P</searchLink>; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sundström+J%22">Sundström J</searchLink>; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Langenberg+C%22">Langenberg C</searchLink>; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tobin+MD%22">Tobin MD</searchLink>; Department of Health Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Giedraitis+V%22">Giedraitis V</searchLink>; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Luan+J%22">Luan J</searchLink>; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tuomilehto+J%22">Tuomilehto J</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kutalik+Z%22">Kutalik Z</searchLink>; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ripatti+S%22">Ripatti S</searchLink>; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Salomaa+V%22">Salomaa V</searchLink>; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Girotto+G%22">Girotto G</searchLink>; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Trompet+S%22">Trompet S</searchLink>; Department Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jukema+JW%22">Jukema JW</searchLink>; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Harst+P%22">van der Harst P</searchLink>; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ridker+PM%22">Ridker PM</searchLink>; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Giulianini+F%22">Giulianini F</searchLink>; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vitart+V%22">Vitart V</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Goel+A%22">Goel A</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Harris+SE%22">Harris SE</searchLink>; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Deary+IJ%22">Deary IJ</searchLink>; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Most+PJ%22">van der Most PJ</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oldehinkel+AJ%22">Oldehinkel AJ</searchLink>; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Keavney+BD%22">Keavney BD</searchLink>; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Manchester Heart Institute, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LJ%22">Scott LJ</searchLink>; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Boutin+T%22">Boutin T</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Mamasoula+C%22">Mamasoula C</searchLink>; Population Health Sciences Institute, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Järvelin+MR%22">Järvelin MR</searchLink>; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Lehrstuhl für Epidemiologie, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lakatta+EG%22">Lakatta EG</searchLink>; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cucca+F%22">Cucca F</searchLink>; Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Italy.<br /><searchLink fieldCode="AU" term="%22Hui+J%22">Hui J</searchLink>; Busselton Population Medical Research Institute, Perth, Western Australia, Australia.; School of Population and Global Health, The University of Western Australia, Nedlands, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Knekt+P%22">Knekt P</searchLink>; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Enroth+S%22">Enroth S</searchLink>; Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22De+Borst+MH%22">De Borst MH</searchLink>; Department of Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Polašek+O%22">Polašek O</searchLink>; University of Split School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Concas+MP%22">Concas MP</searchLink>; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Catamo+E%22">Catamo E</searchLink>; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Cocca+M%22">Cocca M</searchLink>; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Li-Gao+R%22">Li-Gao R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hofer+E%22">Hofer E</searchLink>; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Schmidt+H%22">Schmidt H</searchLink>; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Spedicati+B%22">Spedicati B</searchLink>; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Waldenberger+M%22">Waldenberger M</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Strachan+DP%22">Strachan DP</searchLink>; Population Health Sciences Institute St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Laan+M%22">Laan M</searchLink>; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Teumer+A%22">Teumer A</searchLink>; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Dörr+M%22">Dörr M</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Gudnason+V%22">Gudnason V</searchLink>; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Kopavogur, Iceland.<br /><searchLink fieldCode="AU" term="%22Cook+JP%22">Cook JP</searchLink>; Department of Health Data Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Ruggiero+D%22">Ruggiero D</searchLink>; IRCCS Neuromed, Pozzilli, Italy.; Institute of Genetics and Biophysics - 'A. Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Kolcic+I%22">Kolcic I</searchLink>; Algebra University College, Zagreb, Croatia.; Department of Public Health, University of Split School of Medicine, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Traglia+M%22">Traglia M</searchLink>; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Raitakari+OT%22">Raitakari OT</searchLink>; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Johnson+AD%22">Johnson AD</searchLink>; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; The Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Newton-Cheh+C%22">Newton-Cheh C</searchLink>; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+MJ%22">Brown MJ</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Dominiczak+AF%22">Dominiczak AF</searchLink>; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Sever+PJ%22">Sever PJ</searchLink>; International Centre for Circulatory Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Poulter+N%22">Poulter N</searchLink>; School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chambers+JC%22">Chambers JC</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Elosua+R%22">Elosua R</searchLink>; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.; CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain.; Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Siscovick+D%22">Siscovick D</searchLink>; New York Academy of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Metspalu+A%22">Metspalu A</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Strawbridge+RJ%22">Strawbridge RJ</searchLink>; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Health Data Research UK, Glasgow, UK.; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hamsten+A%22">Hamsten A</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hottenga+JJ%22">Hottenga JJ</searchLink>; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Geus+E%22">de Geus E</searchLink>; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Morris+AD%22">Morris AD</searchLink>; Data Science, University of Edinburgh, Edinburgh, UK.; Health Data Research UK, London, UK.<br /><searchLink fieldCode="AU" term="%22Palmer+CNA%22">Palmer CNA</searchLink>; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Nolte+IM%22">Nolte IM</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Milaneschi+Y%22">Milaneschi Y</searchLink>; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Marten+J%22">Marten J</searchLink>; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wright+A%22">Wright A</searchLink>; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zeggini+E%22">Zeggini E</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Howson+JMM%22">Howson JMM</searchLink>; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22O'Donnell+CJ%22">O'Donnell CJ</searchLink>; VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spector+T%22">Spector T</searchLink>; Department of Twin Research, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nalls+MA%22">Nalls MA</searchLink>; Center for Alzheimer's and Related Dementias, NIA/NINDS, NIH, Bethesda, MD, USA.; Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Simonsick+EM%22">Simonsick EM</searchLink>; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22van+Duijn+CM%22">van Duijn CM</searchLink>; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Butterworth+AS%22">Butterworth AS</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Danesh+JN%22">Danesh JN</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Human Genetics, The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Menni+C%22">Menni C</searchLink>; Department of Twin Research and Genetic Epidemiology, London, UK.<br /><searchLink fieldCode="AU" term="%22Wareham+NJ%22">Wareham NJ</searchLink>; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Khaw+KT%22">Khaw KT</searchLink>; Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sun+YV%22">Sun YV</searchLink>; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.; VA Atlanta Healthcare System, Decatur, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PWF%22">Wilson PWF</searchLink>; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Visscher+PM%22">Visscher PM</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Denny+JC%22">Denny JC</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Levy+D%22">Levy D</searchLink>; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Edwards+TL%22">Edwards TL</searchLink>; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. todd.l.edwards@vumc.org.<br /><searchLink fieldCode="AU" term="%22Munroe+PB%22">Munroe PB</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Snieder+H%22">Snieder H</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Warren+HR%22">Warren HR</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.
– Name: AuthorCorporate
  Label: Corporate Authors
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  Data: <searchLink fieldCode="CA" term="%22Million+Veteran+Program%22">Million Veteran Program</searchLink><br /><searchLink fieldCode="CA" term="%22Lifelines+Cohort+Study%22">Lifelines Cohort Study</searchLink><br /><searchLink fieldCode="CA" term="%22CHARGE+consortium%22">CHARGE consortium</searchLink><br /><searchLink fieldCode="CA" term="%22ICBP+Consortium%22">ICBP Consortium</searchLink>
– Name: TitleSource
  Label: Source
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2024 May; Vol. 56 (5), pp. 778-791. <i>Date of Electronic Publication: </i>2024 Apr 30.
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  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1038/s41588-024-01714-w
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      – Code: eng
        Text: English
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        StartPage: 778
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      – TitleFull: Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
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            – D: 01
              M: 05
              Text: 2024 May
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
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              Value: 56
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              Value: 5
          Titles:
            – TitleFull: Nature genetics
              Type: main
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