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The intrinsic substrate specificity of the human tyrosine kinome.

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Title: The intrinsic substrate specificity of the human tyrosine kinome.
Authors: Yaron-Barir TM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Joughin BA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Huntsman EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Kerelsky A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Cizin DM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Cohen BM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Regev A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Song J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Vasan N; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA., Lin TY; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Discovery Technologies, Calico Life Sciences, South San Francisco, CA, USA., Orozco JM; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Schoenherr C; Cancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Sagum C; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wynn RM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tso SC; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chuang DT; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li L; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China., Li SS; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada., Creixell P; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Cancer Research UK Cambridge Institute, University of Cambridge Li Ka Shing Centre, Cambridge, UK., Krismer K; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Takegami M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Lee H; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Zhang B; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Lu J; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Cossentino I; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Landry SD; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Uduman M; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Blenis J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Elemento O; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Frame MC; Cancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hornbeck PV; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Lewis_Cantley@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Lewis_Cantley@dfci.harvard.edu.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Lewis_Cantley@dfci.harvard.edu., Turk BE; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. ben.turk@yale.edu., Yaffe MB; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Division of Acute Care Surgery, Trauma, and Surgical Critical Care, and Division of Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. myaffe@mit.edu., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. jaredl_johnson@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. jaredl_johnson@dfci.harvard.edu.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. jaredl_johnson@dfci.harvard.edu.
Source: Nature [Nature] 2024 May; Vol. 629 (8014), pp. 1174-1181. Date of Electronic Publication: 2024 May 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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