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Computationally restoring the potency of a clinical antibody against Omicron.

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Title: Computationally restoring the potency of a clinical antibody against Omicron.
Authors: Desautels TA; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Arrildt KT; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Zemla AT; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Lau EY; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Zhu F; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Ricci D; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Cronin S; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zost SJ; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Binshtein E; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Scheaffer SM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Dadonaite B; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., Petersen BK; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Engdahl TB; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Chen E; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Handal LS; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Hall L; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Goforth JW; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Vashchenko D; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Nguyen S; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA.; Google, Alphabet Inc., Mountain View, CA, USA., Weilhammer DR; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Lo JK; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Rubinfeld B; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Saada EA; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Weisenberger T; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Lee TH; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Whitener B; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Vir Biotechnology, San Francisco, CA, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ladd A; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Silva MS; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Haluska RM; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Grzesiak EA; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Earnhart CG; Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, US Department of Defense, Frederick, MD, USA., Hopkins S; Joint Rsearch and Development Inc., Stafford, VA, USA., Bates TW; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Thackray LB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Segelke BW; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA., Lillo AM; Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM, USA., Sundaram S; Center for Bioengineering, Lawrence Livermore National Laboratory, Livermore, CA, USA., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Carnahan RH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Faissol DM; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA. faissol1@llnl.gov.
Corporate Authors: Tri-lab COVID-19 Consortium
Source: Nature [Nature] 2024 May; Vol. 629 (8013), pp. 878-885. Date of Electronic Publication: 2024 May 08.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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