Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5-17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial.

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Title: Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5-17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial.
Authors: Juraska M; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA. Electronic address: mjuraska@fredhutch.org., Early AM; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Li L; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA., Schaffner SF; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Lievens M; GSK, Wavre, Belgium., Khorgade A; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Simpkins B; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA., Hejazi NS; Harvard T.H. Chan School of Public Health, Department of Biostatistics, Boston, MA, USA., Benkeser D; Emory University Rollins School of Public Health, Department of Biostatistics and Bioinformatic, Atlanta, GA, USA., Wang Q; Department of Statistics, University of Washington, Seattle, WA, USA., Mercer LD; PATH, Seattle, WA, USA., Adjei S; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Agbenyega T; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Anderson S; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Ansong D; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., Bii DK; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Buabeng PBY; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana., English S; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Fitzgerald N; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Grimsby J; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Kariuki SK; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Otieno K; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Roman F; GSK, Wavre, Belgium., Samuels AM; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Kisumu, Kenya; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Westercamp N; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Ockenhouse CF; PATH, Seattle, WA, USA., Ofori-Anyinam O; GSK, Wavre, Belgium., Lee CK; PATH, Seattle, WA, USA., MacInnis BL; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA., Wirth DF; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA, USA., Gilbert PB; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA; Department of Biostatistics, University of Washington, Hans Rosling Center for Population Health, Seattle, WA, USA., Neafsey DE; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA, USA. Electronic address: neafsey@hsph.harvard.edu.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2024 Sep; Vol. 24 (9), pp. 1025-1036. Date of Electronic Publication: 2024 May 06.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
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  Data: Genotypic analysis of RTS,S/AS01<subscript>E</subscript> malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5-17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Juraska+M%22">Juraska M</searchLink>; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA. Electronic address: mjuraska@fredhutch.org.<br /><searchLink fieldCode="AU" term="%22Early+AM%22">Early AM</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schaffner+SF%22">Schaffner SF</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lievens+M%22">Lievens M</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Khorgade+A%22">Khorgade A</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Simpkins+B%22">Simpkins B</searchLink>; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hejazi+NS%22">Hejazi NS</searchLink>; Harvard T.H. Chan School of Public Health, Department of Biostatistics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Benkeser+D%22">Benkeser D</searchLink>; Emory University Rollins School of Public Health, Department of Biostatistics and Bioinformatic, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Statistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mercer+LD%22">Mercer LD</searchLink>; PATH, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Adjei+S%22">Adjei S</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Agbenyega+T%22">Agbenyega T</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Anderson+S%22">Anderson S</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ansong+D%22">Ansong D</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22Bii+DK%22">Bii DK</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Buabeng+PBY%22">Buabeng PBY</searchLink>; Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.<br /><searchLink fieldCode="AU" term="%22English+S%22">English S</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+N%22">Fitzgerald N</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Grimsby+J%22">Grimsby J</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kariuki+SK%22">Kariuki SK</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Otieno+K%22">Otieno K</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Roman+F%22">Roman F</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Samuels+AM%22">Samuels AM</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Kisumu, Kenya; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Westercamp+N%22">Westercamp N</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ockenhouse+CF%22">Ockenhouse CF</searchLink>; PATH, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ofori-Anyinam+O%22">Ofori-Anyinam O</searchLink>; GSK, Wavre, Belgium.<br /><searchLink fieldCode="AU" term="%22Lee+CK%22">Lee CK</searchLink>; PATH, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22MacInnis+BL%22">MacInnis BL</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wirth+DF%22">Wirth DF</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+PB%22">Gilbert PB</searchLink>; Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA; Department of Biostatistics, University of Washington, Hans Rosling Center for Population Health, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Neafsey+DE%22">Neafsey DE</searchLink>; Broad Institute, Infectious Disease and Microbiome Program, Cambridge, MA, USA; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA, USA. Electronic address: neafsey@hsph.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2024 Sep; Vol. 24 (9), pp. 1025-1036. <i>Date of Electronic Publication: </i>2024 May 06.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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