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Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.

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Title: Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.
Authors: Hayhow TG; Oncology R&D, AstraZeneca, Cambridge, UK. thomas.hayhow@astrazeneca.com., Williamson B; Oncology R&D, AstraZeneca, Cambridge, UK., Lawson M; Oncology R&D, AstraZeneca, Cambridge, UK., Cureton N; Oncology R&D, AstraZeneca, Cambridge, UK., Braybrooke EL; Oncology R&D, AstraZeneca, Cambridge, UK., Campbell A; Pharmaceutical Sciences, AstraZeneca, Cambridge, UK., Carbajo RJ; Oncology R&D, AstraZeneca, Cambridge, UK., Cheraghchi-Bashi A; Oncology R&D, AstraZeneca, Cambridge, UK., Chiarparin E; Oncology R&D, AstraZeneca, Cambridge, UK., Diène CR; Oncology R&D, AstraZeneca, Cambridge, UK., Fallan C; Oncology R&D, AstraZeneca, Cambridge, UK., Fisher DI; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Goldberg FW; Oncology R&D, AstraZeneca, Cambridge, UK., Hopcroft L; Oncology R&D, AstraZeneca, Cambridge, UK., Hopcroft P; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Jackson A; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Kettle JG; Oncology R&D, AstraZeneca, Cambridge, UK., Klinowska T; Oncology R&D, AstraZeneca, Cambridge, UK., Künzel U; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Lamont G; Oncology R&D, AstraZeneca, Cambridge, UK., Lewis HJ; Oncology R&D, AstraZeneca, Cambridge, UK., Maglennon G; Oncology R&D, AstraZeneca, Cambridge, UK., Martin S; Oncology R&D, AstraZeneca, Cambridge, UK., Gutierrez PM; Oncology R&D, AstraZeneca, Cambridge, UK., Morrow CJ; Oncology R&D, AstraZeneca, Cambridge, UK., Nikolaou M; Oncology R&D, AstraZeneca, Cambridge, UK., Nissink JWM; Oncology R&D, AstraZeneca, Cambridge, UK., O'Shea P; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Polanski R; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Schade M; Oncology R&D, AstraZeneca, Cambridge, UK., Scott JS; Oncology R&D, AstraZeneca, Cambridge, UK., Smith A; Oncology R&D, AstraZeneca, Cambridge, UK., Weber J; Oncology R&D, AstraZeneca, Cambridge, UK., Wilson J; Oncology R&D, AstraZeneca, Cambridge, UK., Yang B; Oncology R&D, AstraZeneca, Waltham, MA, USA., Crafter C; Oncology R&D, AstraZeneca, Cambridge, UK.
Source: Communications biology [Commun Biol] 2024 May 13; Vol. 7 (1), pp. 563. Date of Electronic Publication: 2024 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2024 May 13; Vol. 7 (1), pp. 563. <i>Date of Electronic Publication: </i>2024 May 13.
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