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Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta.

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Title: Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta.
Authors: Infante A; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain., Alcorta-Sevillano N; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain; Department of Cell Biology and Histology, University of Basque Country UPV/EHU, Leioa, Spain., Macías I; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain., Cabodevilla L; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain., Medhat D; Medical Biochemistry Department, National Research Centre, Dokki, Giza, Egypt., Lafaver B; Department of Biochemistry, University of Missouri, Columbia, USA., Crawford TK; Department of Biochemistry, University of Missouri, Columbia, USA., Phillips CL; Department of Biochemistry, University of Missouri, Columbia, USA., Bueno AM; Department of Orthopedic Surgery, Getafe University Hospital, Madrid, Spain., Sagastizabal B; Department of Endocrinology, Getafe University Hospital, Madrid, Spain., Arroyo M; Department of Traumatology, Basurto Hospital, Bilbao, Spain., Campino A; Service of Pharmacy, Cruces University Hospital, Barakaldo, Spain., Gerovska D; Computational Biology and Systems Biomedicine Research Group, Biogipuzkoa Health Research Institute, Donostia, Spain., Araúzo-Bravo M; Computational Biology and Systems Biomedicine Research Group, Biogipuzkoa Health Research Institute, Donostia, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao 48009, Spain; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Spain., Gener B; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain; Service of Genetics, Cruces University Hospital, Barakaldo, Spain., Rodríguez CI; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain. Electronic address: cirodriguez@osakidetza.eus.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jun; Vol. 175, pp. 116725. Date of Electronic Publication: 2024 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta.
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  Data: <searchLink fieldCode="AU" term="%22Infante+A%22">Infante A</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Alcorta-Sevillano+N%22">Alcorta-Sevillano N</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain; Department of Cell Biology and Histology, University of Basque Country UPV/EHU, Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Macías+I%22">Macías I</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Cabodevilla+L%22">Cabodevilla L</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Medhat+D%22">Medhat D</searchLink>; Medical Biochemistry Department, National Research Centre, Dokki, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Lafaver+B%22">Lafaver B</searchLink>; Department of Biochemistry, University of Missouri, Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+TK%22">Crawford TK</searchLink>; Department of Biochemistry, University of Missouri, Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+CL%22">Phillips CL</searchLink>; Department of Biochemistry, University of Missouri, Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Bueno+AM%22">Bueno AM</searchLink>; Department of Orthopedic Surgery, Getafe University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sagastizabal+B%22">Sagastizabal B</searchLink>; Department of Endocrinology, Getafe University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Arroyo+M%22">Arroyo M</searchLink>; Department of Traumatology, Basurto Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Campino+A%22">Campino A</searchLink>; Service of Pharmacy, Cruces University Hospital, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Gerovska+D%22">Gerovska D</searchLink>; Computational Biology and Systems Biomedicine Research Group, Biogipuzkoa Health Research Institute, Donostia, Spain.<br /><searchLink fieldCode="AU" term="%22Araúzo-Bravo+M%22">Araúzo-Bravo M</searchLink>; Computational Biology and Systems Biomedicine Research Group, Biogipuzkoa Health Research Institute, Donostia, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao 48009, Spain; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Spain.<br /><searchLink fieldCode="AU" term="%22Gener+B%22">Gener B</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain; Service of Genetics, Cruces University Hospital, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+CI%22">Rodríguez CI</searchLink>; Stem Cells and Advanced Therapies Group, Biobizkaia Health Research Institute, Barakaldo, Spain. Electronic address: cirodriguez@osakidetza.eus.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2024 Jun; Vol. 175, pp. 116725. <i>Date of Electronic Publication: </i>2024 May 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.biopha.2024.116725
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      – Code: eng
        Text: English
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        StartPage: 116725
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      – TitleFull: Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta.
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              Text: 2024 Jun
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